枣仁安神胶囊联合认知行为治疗在脑梗死后睡眠障碍患者中应用的临床观察  

Clinical observation on the application of Zaoren Anshen Capsules combined with cognitive-behavioral therapy in patients with sleep disorders after cerebral infarction

作　　者：王新生 谢芳清 吕志强 曾小明 刘鹏 WANG Xinsheng;XIE Fangqing;LYU Zhiqiang;ZENG Xiaoming;LIU Peng(Department of Emergency,Xingguo Hospital Affiliated to Gannan Medical University,Jiangxi Province,Xingguo342400,China;Department of Intensive Care,Xingguo Hospital Affiliated to Gannan Medical University,Jiangxi Province,Xingguo342400,China;Department of Neurology,Xingguo Hospital Affiliated to Gannan Medical University,Jiangxi Province,Xingguo342400,China;Department of Psychiatry,Xingguo Hospital Affiliated to Gannan Medical University,Jiangxi Province,Xingguo342400,China)

机构地区：[1]赣南医科大学附属兴国医院急诊科,江西兴国342400 [2]赣南医科大学附属兴国医院重症医学科,江西兴国342400 [3]赣南医科大学附属兴国医院神经内科,江西兴国342400 [4]赣南医科大学附属兴国医院精神科,江西兴国342400

出　　处：《中国当代医药》2024年第22期42-46,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023A0209)。

摘　　要：目的分析脑梗死后睡眠障碍应用枣仁安神胶囊联合认知行为治疗的临床效果。方法选取2022年11月至2023年11月赣南医科大学附属兴国医院收治的60例脑梗死后睡眠障碍患者为研究对象,根据随机数字表法分为对照组与观察组,每组各30例。对照组应用右佐匹克隆片+认知行为治疗,观察组在对照组方法的基础上联合枣仁安神胶囊治疗,比较两组的睡眠质量、心理状态、及后遗症表达情况。结果治疗后,观察组的匹兹堡睡眠指数(PSQI)各维度评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组的美国国立卫生研究院卒中量表(NIHSS)、神经精神症状问卷(NPI)评分均低于对照组,简易智力状态检查表(MMSE)、Fugl-Meyer评定(FMA)评分均高于对照组,差异有统计学意义(P<0.05)。结论脑梗死后睡眠障碍应用枣仁安神胶囊联合认知行为治疗可改善患者的睡眠质量与心理状态,促进脑梗死后遗症的改善。Objective To analyze the clinical effect of Zaoren Anshen Capsules combined with cognitive-behavioral therapy for sleep disorders after cerebral infarction.Methods A total of 60 patients with sleep disorders after cerebral infarction admitted to Xingguo Hospital Affiliated to Gannan Medical University from November 2022 to November 2023 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 30 cases in each group.The control group was treated with Dexzopiclone Tablets+cognitive behavioral therapy,and the observation group was treated with Zaoren Anshen Capsules on the basis of the control group.The sleep quality,psychological state,and sequelae of the two groups were compared.Results After treatment,the Pittsburgh sleep quality index(PSQI)scores of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).After treatment,the scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of the National Institutes of Health stroke scale(NIHSS)and neuropsychiatric inventory(NPI)in the observation group were lower than those in the control group,and the scores of the mini-mental state examination(MMSE)and the Fugl-Meyer assessment(FMA)were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion The application of Zaoren Anshen Capsules combined with cognitive-behavioral therapy can improve the sleep quality and psychological state of patients with post-stroke sleep disorders,and promote the improvement of post-stroke sequelae.

关 键 词：脑梗死后遗症 睡眠障碍 枣仁安神胶囊 右佐匹克隆片 认知行为治疗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]