抗NMDAR脑炎的病因及诊疗研究进展  

Research progress on the etiology and diagnosis and treatment of anti NMDAR encephalitis

作　　者：徐振宏 凌鑫 段晓梅 唐北沙 Xu Zhenhong;Ling Xin;Duan Xiaomei;Tang Beisha(Department of Neurology,The First Affliated Hospital,Multi-Omics Research Center for Brain Disorders,Hengyang Medical School,University of South China,Clinical Research Center For Immune-Related Encephalopathy in Hunan Province,Hengyang Medical School,University of South China,Hengyang 421000,China;Department of Neurology,Xiangya Hospital,Central South University,National Clinical Research Center for Geriatric Disorders(Xiangya Hospital),Changsha 410008,China)

机构地区：[1]南华大学附属第一医院神经内科、脑疾病多组学研究中心,湖南省免疫相关性脑病临床研究中心,衡阳421000 [2]中南大学湘雅医院神经内科、国家老年疾病临床医学研究中心(湘雅医院),长沙410008

出　　处：《中国医师杂志》2024年第7期990-994,共5页Journal of Chinese Physician

摘　　要：抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是一种罕见的自身免疫性脑炎,其病因与临床表现的多样性使其备受关注,但目前抗NMDAR脑炎的病因及发病机制尚未完全明确,其诊治仍存在一定的局限性。本综述主要探讨驱动疾病发生的环境遗传因素及有利于诊断疾病的生物学指标,并阐述目前的免疫调节和新兴治疗途径,指出潜在的靶向干预措施,并展望其面临的挑战与未来的发展方向。Anti N-methyl-D-aspartate receptor(NMDAR)encephalitis is a rare autoimmune encephalitis,and its diverse etiology and clinical manifestations have attracted attention.However,the etiology and pathogenesis of anti NMDAR encephalitis are not yet fully understood,and its diagnosis and treatment still have certain limitations.This review mainly explores the environmental genetic factors that drive the occurrence of diseases and the biological indicators that are beneficial for diagnosis.It also elaborates on the current immune regulation and emerging treatment pathways,points out potential targeted interventions,and looks forward to the challenges and future development directions they face.

关 键 词：抗N-甲基-D-门冬氨酸受体脑炎 生物标记 

分 类 号：R742.9[医药卫生—神经病学与精神病学]