Praseodymium metal nanorods as a 5-fluorouracil carrier  

作　　者：Varnitha Manikantan Govindaraj Sri Varalakshmi Ujma Ashapak Tamboli Archana Sumohan Pillai Aleyamma Alexander Anushka Lucas Bose Allben Akash Israel V.M.V.Enoch 

机构地区：[1]Centre for Nanoscience and Genomics,Karunya Institute of Technology and Sciences(Deemed University),Coimbatore,641114,Tamil Nadu,India [2]Department of Applied Chemistry,Karunya Institute of Technology and Sciences(Deemed University),Coimbatore,641114,Tamil Nadu,India

出　　处：《Journal of Rare Earths》2024年第7期1328-1336,I0005,共10页稀土学报（英文版）

基　　金：funding through the I-STEM program,organized by the Office of the Principal Scientific Adviser to the Government of India。

摘　　要：Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been increasing.In such an aspect,lanthanide metal nanoparticles are particularly intriguing.Herein,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting agent.The material was made as a composite with the supramolecular host polymer,poly-β-cyclodextrin.The praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron microscopy.The nanostructures are a long rod-shaped material with 2.0±0.1μm in length and 230±10 nm in width.The material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 Oe.The nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from the nanocarrier(polymer-containing praseodymium nanoparticles)and proceeds for above 250 h.The in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on MCF-7 and Vero(non-cancerous)cell lines.The cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are unaffected.The IC_(50)values on the cell lines are reported.

关 键 词：Metal nanoparticles PRASEODYMIUM Poly-cyclodextrin Drug delivery ANTICANCER activity Rare earths 

分 类 号：R943[医药卫生—药剂学] TQ460.4[医药卫生—药学] TB383.1[化学工程—制药化工]