Therapeutic potential and pharmacological mechanism of visnagin  

作　　者：Poonam Yadav Sumeet Kumar Singh Sayantap Datta Saloni Verma Aarti Verma Arnab Rakshit Anjana Bali Jasvinder Singh Bhatti Amit Khurana Umashanker Navik 

机构地区：[1]Department of Pharmacology,School of Health Sciences,Central University of Punjab,Bathinda,Punjab 151401,India [2]Department of Pharmacological and Pharmaceutical Sciences,College of Pharmacy,University of Houston,Houston,TX 77204-5000,USA [3]Department of Human Genetics and Molecular Medicine,School of Health Sciences,Central University of Punjab,Bathinda,Punjab 151401,India

出　　处：《Journal of Integrative Medicine》2024年第4期399-412,共14页结合医学学报（英文版）

摘　　要：Visnagin is a furanochromone and one of the most important compound in the Ammi visnaga(L.)Lam(a synonym of Visnaga daucoides Gaertn.)plant,which is used to cure various ailments.Many investigations into the bioactive properties of visnagin have been studied to date.The literature on visnagin demonstrates its biological properties,including anti-inflammatory,anti-diabetic,and beneficial effects in cardiovascular and renal diseases.Moreover,visnagin improves sperm quality parameters,stimulates steroidogenesis,and increases serum gonadotropins and testosterone levels,while decreasing proinflammatory cytokines,oxidative damage,genomic instability,and it modulates apoptosis.Thus,visnagin has emerged as an exciting lead for further research,owing to its potential in various unmet clinical needs.The current review summarized its basic structure,pharmacokinetics,and pharmacological effects,focusing on its mechanisms of action.The review will help to understand the potential of visnagin as an alternative treatment strategy for several diseases and provide insight into research topics that need further exploration for visnagin’s safe clinical use.

关 键 词：Visnagin PHYTOCHEMICAL ANTI-INFLAMMATORY Ammi visnaga L. Visnaga daucoides Gaertn CANCER 

分 类 号：R285[医药卫生—中药学]