山西省非贲门胃癌遗传流行病学研究  

Genetic Epidemiology Study of Non-cardiac Gastric Cancer in Shanxi Province

作　　者：郭雪蓉[1] 赵冰玉 韩小友[1] 王媛[1] 马朝辉[1] Guo Xuerong;Zhao Bingyu;Han Xiaoyou;Wang Yuan;Ma Chaohui(Department of Cancer Prevention and Control,Shanxi Cancer Hospital(i.e.Shanxi Hospital,Caner Hospital,Chinese Academy of Medical Sciences,or Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030013,)Shanxi,China)

机构地区：[1]山西省肿瘤医院/中国医学科学院肿瘤医院山西医院/山西医科大学附属肿瘤医院肿瘤防控办公室,太原030013

出　　处：《肿瘤预防与治疗》2024年第7期578-584,共7页Journal of Cancer Control And Treatment

基　　金：美国国家癌症研究所(NCI)合作课题(编号:NCI66211/CQ600211)。

摘　　要：目的:通过对特定人群开展的遗传流行病学调查,探讨遗传、环境因素在山西省非贲门胃癌发生中的作用,为非贲门胃癌的病因学研究、早期预防和早期治疗提供科学的依据。方法:本研究采用病例对照研究设计,并分别对病例组、对照组开展家系资料收集。共收集到在山西省肿瘤医院住院的426例非贲门胃癌有效病例。对其中379例病例按照1∶1配对方式建立对照,了解病例和对照的亲属中恶性肿瘤发病情况,做家族聚集性分析。应用Li-Mante-Gart法对426个先证者家系做分离分析,采用Falconer法计算遗传度,应用Greenwood和Yule法做出生顺序分析。结果:非贲门胃癌先证者家系非贲门胃癌患病率Ⅰ级亲属>Ⅱ级亲属>Ⅲ级亲属(χ^(2)=37.065,P<0.001),提示山西省非贲门胃癌的发生情况具有家族聚集性;Li-Mantel-Gart法做分离分析,分离比为0.021(95%CI:0.018~0.024),结果显示非贲门胃癌属于多基因遗传性疾病。Ⅰ级亲属遗传度为11.10%±5.05%,提示遗传因素的作用是山西省非贲门胃癌的发病原因之一,但不是主要因素;出生顺序分析显示山西省非贲门胃癌的发生与出生顺序的先后是有关系的,更易发生于出生顺序较早者,提示环境因素对非贲门胃癌的发生有一定的影响作用。结论:在山西省,非贲门胃癌的发生情况具有家族聚集性倾向,遗传因素主导因素起一定作用,但不是主要作用,环境因素的影响更大。Objective:By conducting genetic epidemiology surveys,we explore the roles of genetic and environmental factors in the occurrence of non-cardia gastric cancer in Shanxi Province,and provide scientific basis for the etiological research and early prevention and treatment of gastric cancer.Methods:The data were collected by combining pedigree investigation with case-control study,and the data of 426 non-cardia gastric cancer patients hospitalized in Shanxi Cancer Hospital were investigated.For 379 of these cases,controls were established in a 1∶1 matching manner to investigate the incidence of malignant tumors in the relatives of patients and controls,and to perform a family aggregation analysis.For 426 proband families,Li-Mantel-Gart method was used for segregation analysis,Falconer method was used to calculate heritability,and Greenwood and Yule methods were applied for birth order analysis.Results:The prevalence of non-cardia gastric cancer in the first-degree relatives of the non-cardia gastric cancer proband families was higher than that in the second-degree relatives,followed by the third-degree relatives(χ^(2)=37.065,P<0.001),indicating that the occurrence of non-cardia gastric cancer in Shanxi Province has family aggregation.The segregation ratio in the Li-Mantel-Gart method was 0.021(95%CI:0.018~0.024),and the results showed that non-cardia gastric cancer was a polygenic inherited disease.The heritability of the first-degree relatives was 11.10%±5.05%,indicating that genetic factor was one of the factors in the pathogenesis of non-cardia gastric cancer in Shanxi Province,but not the main factor.Birth order analysis showed that the occurrence of non-cardia gastric cancer in Shanxi Province was related to the sequence of birth,and it is more likely to occur in those with an earlier birth order,suggesting that environmental factors have a certain impact on the occurrence of non-cardia gastric cancer.Conclusion:The occurrence of non-cardia gastric cancer in Shanxi Province is characterized by family aggrega

关 键 词：非贲门胃癌 遗传流行病学 分离分析 遗传度 出生顺序研究 

分 类 号：R735.2[医药卫生—肿瘤]