智能生物反应器装备制造进展  

Progress in the manufacture of intelligent bioreactor equipment

作　　者：刘可意 汪俊卿[1,2] 傅凯 李峰 王瑞明 李丕武[1,2] LIU Keyi;WANG Junqing;FU Kai;LI Feng;WANG Ruiming;LI Piwu(College of Bioengineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China;State Key Laboratory of Biobased Material and Green Papermaking,Jinan 250353,China;Shandong Shendong intelligent equipment Co.Ltd.,Dezhou 253000,China)

机构地区：[1]齐鲁工业大学(山东省科学院)生物工程学部,山东济南250353 [2]生物基材料与绿色造纸国家重点实验室,山东济南250353 [3]山东申东智能装备有限公司,山东德州253000

出　　处：《食品与发酵工业》2024年第15期409-416,共8页Food and Fermentation Industries

基　　金：山东省重点研发计划项目(2022CXGC020206)。

摘　　要：生物反应器是生物医药和生物技术产业的核心装备,全球生物反应器市场规模逐年增长,将成为装备制造领域重要的增长点。随着合成生物学和人工智能技术的迅猛发展,高通量、微型化生物反应器已开始应用于工艺开发和优化,大型生物反应器则朝着低能耗、智能化方向发展。生物反应器流场结构的复杂性是导致生物过程放大困难的关键问题之一,需要对反应器内的混合、传质、剪切等要素进行综合研究。为了提高生物反应器效率,需要采用人工智能和机器学习等技术进行数据采集和优化。未来结合生物技术、信息技术和控制技术的高集成度智能生物反应器将在多个领域有更广阔的发展空间。The bioreactor serves as the fundamental equipment in the biomedicine and biotechnology industry,with the global market witnessing continuous growth year after year.It is poised to become a pivotal driver of expansion within the realm of equipment manufacturing.With the rapid advancements in synthetic biology and artificial intelligence technology,high-throughput and miniaturized bioreactors have been implemented for process development and optimization,while large-scale bioreactors are evolving towards low energy consumption and intelligent operation.The intricate flow field structure within a bioreactor poses a significant challenge to scaling up biological processes,necessitating comprehensive research on factors such as mixing,mass transfer,shear stress,among others.To enhance the,techniques like artificial intelligence and machine learning are indispensable for data acquisition and optimization purposes.In the future,highly integrated intelligent bioreactors expertise from various domains including biotechnology,information technology,and control technology will find extensive applications across multiple fields.

关 键 词：生物反应器 计算流体力学 传感器 智能化 机器学习 

分 类 号：TQ920.5[轻工技术与工程—发酵工程]