MACF1 deficiency suppresses tooth mineralization through IGF1 mediated crosstalk between odontoblasts and ameloblasts  

作　　者：Wuxia Qiu Xiao Lin Shaoqing Yang Zhihao Chen Kewen Zhang Chaofei Yang Yu Li Zhiping Miao Xiaoni Deng Xiaohong Duan Airong Qian 

机构地区：[1]Lab for Bone Metabolism,Xi’an Key Laboratory of Special Medicine and Health Engineering,Key Lab for Space Biosciences and Biotechnology,Research Center for Special Medicine and Health Systems Engineering,NPU-UAB Joint Laboratory for Bone Metabolism,School of Life Sciences,Northwestern Polytechnical University,Xi’an,Shaanxi 710072,China [2]State Key Laboratory of Military Stomatology,National Clinical Research Center for Oral Diseases,Department of Oral Biology,Clinic of Oral Rare and Genetic Diseases,School of Stomatology,The Fourth Military Medical University,Xi’an,Shaanxi 710032,China [3]School of Chemical Engineering,Sichuan University of Science&Engineering,Zigong,Sichuan 643000,China [4]Research&Development Institute of Northwestern Polytechnical University in Shenzhen,Shenzhen,Guangdong 518063,China [5]Puyang Institute of Technology,Henan University,Puyang,Henan 457000,China

出　　处：《Genes & Diseases》2024年第5期9-12,共4页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.30970706,81700784,81974145);the Fundamental Research Funds for the Central Universities(China)(No.D5000210746);the Key Research and Development Project of Shaanxi Province(China)(No.2021SF-293,2021SF-242);the Talent Introduction Project of Sichuan University of Science and Engineering(No.2022RC01);the Guangdong Basic and Applied Basic Research Foundation(China)(No.2023A1515030047).

摘　　要：Tooth mineralization is a ubiquitous and tightly regulated process involving complicated interactions between dental epithelium and mesenchyme.Key molecules in tooth mineralization remain poorly identified.Microtubule actin cross-linking factor 1(MACF1)is a spectraplakin protein that plays pivotal roles in the brain,muscle,lung,and bone developmental process.^(1-3) To study the specific functions of MACF1 in bone formation,we established Macf1 conditional knockout mice using the Cre-LoxP system driven by Osxterix promoter(Osx-Cre;Macf1^(f/f)).^(2) Not surprisingly,Osx-Cre;Macf1^(f/f) mice displayed the phenotypes of delayed ossification and decreased bone mass.Moreover,the OsxCre;Macf1^(f/f) mice unexpectedly showed a white and opaque appearance of incisors,contrary to the normal yellowbrown and transparent incisors.Since Osxterix is expressed in dental mesenchyme during tooth development,the abnormal tooth appearance might imply a new function of MACF1 in odontoblasts,or even ameloblasts.Therefore,the present study aimed to investigate the role of MACF1 during tooth development.

关 键 词：MINERALIZATION linking transparent 

分 类 号：R78[医药卫生—口腔医学]