MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma  

作　　者：Haimin Song Bowen Ni Xuetao Peng Weijuan Xu Shaochun Yang Runwei Yang Ziyu Wang Kaishu Li Rui Lin Yunxiao Zhang Jinglin Guo Kezhi Wu Guangwei Shi Jichao Sun Chunming He Yawei Liu 

机构地区：[1]Department of Neurosurgery,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000,China [2]Department of Neurosurgery&Medical Research Center,Shunde Hospital,Southern Medical University(The First People’s Hospital of Shunde Foshan),Foshan,Guangdong 528300,China [3]Medical Research Center,Shunde Hospital,Southern Medical University(The First People’s Hospital of Shunde Foshan),Foshan,Guangdong 528300,China [4]Bidding and Procurement Office,Shunde Hospital,Southern Medical University(The First People’s Hospital of Shunde Foshan),Foshan,Guangdong 528300,China [5]Department of Neurosurgery,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China [6]Department of Neurosurgery,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan,Guangdong 511518,China [7]Department of Neurosurgery,The First Affiliated Hospital of Shantou University Medical College,Shantou,Guangdong 515041,China [8]Department of Geriatrics,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong 518020,China

出　　处：《Genes & Diseases》2024年第5期70-73,共4页基因与疾病（英文）

基　　金：the Natural Science Foundation of Guangdong Province,China(No.2022A1515012552);Shenzhen Science and Technology Innovation Committee of China(SZSTI;No.JCYJ20220818102611025);Research Initiation Project of Shunde Hospital,Southern Medical University(No.CRSP2022002);Research Initiation Project of the First Affiliated Hospital of Gannan Medical University(No.QD202316);Beijing Sisco Clinical Oncology Research Foundation of China(No.Y-2022METAZMS-0118).

摘　　要：The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely low.We,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.

关 键 词：INVASION PROGNOSIS Clinical 

分 类 号：R739.41[医药卫生—肿瘤]