Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound  

作　　者：Jin Tang Mingxuan Feng Dong Wang Liang Zhang Ke Yang 

机构地区：[1]Pediatric Research Institute,Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Engineering Research Center of Stem Cell Therapy,Chongqing 400014,China [2]Department of Ultrasound,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [3]Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China

出　　处：《Genes & Diseases》2024年第5期163-182,共20页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.81771845);the Chongqing Science and Technology Committee,Chongqing,China(No.CSTB2022NSCQ-MSX0812).

摘　　要：Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation techniques.Sonogenetics,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and magnetogenetics.Upon stimulation with ultrasound,these proteins trigger a cascade of cellular activities and functions.Unlike traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease treatment.This technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and beyond.Although current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of sonogenetics.We discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell therapies.Our objective is to stimulate fresh perspectives for further research in this promising field.

关 键 词：Mechanosensitive channel NEUROMODULATION Sonogenetics ULTRASOUND Ultrasound-sensitive protein 

分 类 号：R394[医药卫生—医学遗传学]