Vitamin D binding protein in psychiatric and neurological disorders:Implications for diagnosis and treatment  

作　　者：Ling Li Bing Han Yan Kong Gaojia Zhang Zhijun Zhang 

机构地区：[1]Research Institution of Neuropsychiatry,School of Medicine,Southeast University,Nanjing,Jiangsu 210009,China [2]Department of Neurology,Affiliated Zhongda Hospital,Nanjing,Jiangsu 210009,China [3]Department of Pharmacology,Jiangsu Provincial Key Laboratory of Critical Care Medicine,School of Medicine,Southeast University,Nanjing,Jiangsu 210009,China [4]Department of Biochemistry and Molecular Biology,School of Medicine,Southeast University,Nanjing,Jiangsu 210009,China [5]Brain Cognition and Brain Disease Institute,Department of Mental Health and Public Health,Faculty of Life and Health Sciences,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,China

出　　处：《Genes & Diseases》2024年第5期324-334,共11页基因与疾病（英文）

基　　金：the National Natural Science Key Foundation of China(No.82130042 to ZJ Zhang);the National Natural Science Foundation of China(No.82371532 to Y Kong).

摘　　要：Vitamin D binding protein(VDBP)serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target organs.VDBP plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin degradation.Recent research has shed light on its potential role in various diseases,leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological disorders.The purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric disorders.By examining the intricate interplay between VDBP and these disorders,this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic avenues.Insights gained from the study of VDBP could pave the way for novel strategies in the diagnosis,prognosis,and treatment of psychiatric and neurological disorders.

关 键 词：Neurological disorder POLYMORPHISM Psychiatric disorder STRUCTURE Vitamin D binding protein 

分 类 号：R741[医药卫生—神经病学与精神病学]