EGFR突变NSCLC组织LncRNA TCF7L2表达及临床病理特征和预后分析  

Expression of long non-coding RNA transcription factor 7-like 2 in epithelial growth factor receptor-mutant non-small cell lung cancer and its association with clinicopathological features and prognosis

作　　者：董跃华[1] 王贵刚[1] 杨燕君[1] 魏玉磊[1] 高永山[1] 姜伟华[1] DONG Yuehua;WANG Guigang;YANG Yanjun;WEI Yulei;GAO Yongshan;JIANG Weihua(Department of Cardiothoracic Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院胸心外科,河北张家口075000

出　　处：《青岛大学学报（医学版）》2024年第3期403-406,共4页Journal of Qingdao University(Medical Sciences)

基　　金：河北省医学科学研究重点课题计划资助项目(20-170779)。

摘　　要：目的 探究长链非编码RNA(LncRNA)转录因子7类似物2(TCF7L2)在表皮生长因子受体基因(EGFR)突变的非小细胞肺癌(NSCLC)组织表达及其与病人临床病理特征和预后相关性。方法 选取2019年3月—2021年6月河北北方学院附属第一医院治疗的EGFR突变NSCLC病人104例为研究对象,分别取其癌组织和癌旁组织应用逆转录PCR(RT-PCR)检测LncRNA TCF7L2的表达,比较不同组织TCF7L2表达及其与临床病理特征和预后的相关性。结果 RT-PCR检测结果显示,癌组织中LncRNA TCF7L2表达量显著高于癌旁组织(t=12.410,P<0.05)。与LncRNA TCF7L2低表达病人比较,高表达者发生淋巴结转移更多、肿瘤体积更大(χ^(2)=4.579、7.762,P<0.05);LncRNA TCF7L2高表达病人6、9和12个月的生存率较低,但差异均无统计学意义(P>0.05)。结论 LncRNA TCF7L2在EGFR突变NSCLC病人癌组织表达高于癌旁组织,且TCF7L2高表达病人的淋巴结转移风险较高、肿瘤体积较大,其生存率可能较低。Objective To investigate the expression of long non-coding RNA(LncRNA)transcription factor 7-like 2(TCF7L2)in epidermal growth factor receptor(EGFR)-mutant non-small cell lung cancer(NSCLC),as well as its association with the clinicopathological features and prognosis of patients.Methods A total of 104 patients with EGFR-mutant NSCLC who were treated in the First Affiliated Hospital of Hebei North University from March 2019 to June 2021 were enrolled as subjects,and RT-PCR was performed for their cancer tissue and paracancerous tissue to measure the expression of LncRNA TCF7L2.The expression level of TCF7L2 was compared between different tissue samples,and its association with clinicopathological features and prognosis was analyzed.Results RT-PCR showed that the expression level of LncRNA TCF7L2 in cancer tissue was significantly higher than that in paracancerous tissue(t=12.410,P<0.05).Compared with the patients with a low expression level of LncRNA TCF7L2,the patients with a high expression level of LncRNA TCF7L2 had a significantly higher incidence rate of lymph node metastases and a significantly larger tumor diameter(χ^(2)=4.579,7.762;P<0.05),as well as a lower survival rate at 6,9,and 12 months(P>0.05).Conclusion For patients with EGFR-mutant NSCLC,the expression level of LncRNA TCF7L2 in cancer tissue is higher than that in paracancerous tissue,and the patients with a high expression level of TCF7L2 tend to have a higher risk of lymph node metastasis,a larger tumor diameter,and a lower survival rate.

关 键 词：癌 非小细胞肺 RNA 未翻译 转录因子7样2蛋白 基因 ERBB-1 病理学 临床 预后 

分 类 号：R730.26[医药卫生—肿瘤] R342.3[医药卫生—临床医学]