原发失眠病人脑电波及脑电频带功率与事件相关电位P300的相关性  

Correlation of brain wave and electroencephalography frequency power with event-related potential P300 in patients with primary insomnia

作　　者：韩婕[1] 邵明菊 高呈飞 赵丽霞[4] HAN Jie;SHAO Mingju;GAO Chengfei;ZHAO Lixia(Department of Neurology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院神经内科,山东青岛266000 [2]青岛大学附属医院呼吸内科,山东青岛266000 [3]青岛大学附属医院康复医学科,山东青岛266000 [4]青岛大学附属医院腹部超声科,山东青岛266000

出　　处：《青岛大学学报（医学版）》2024年第3期422-424,共3页Journal of Qingdao University(Medical Sciences)

基　　金：山东省自然科学基金青年项目(ZR2020QH)。

摘　　要：目的探讨原发失眠病人脑电波、脑电频带功率与事件相关电位P300的相关性,为评估原发失眠对大脑功能及认知功能的影响提供客观依据。方法选取原发性失眠病人31例为研究对象(失眠组),以正常成人31例为对照(正常组),分别进行常规脑电监测、事件相关电位P300(P3a及P3b)检查,分析脑电波占比、脑电频带功率及P3a和P3b潜伏期、波幅等数据及其相关性。结果失眠组与正常组P3a和P3b潜伏期及波幅、脑电α波及β波占比、FTT-β频带功率、FTT-总频带功率差异均具有统计学意义(Z=-6.84~-1.99,P<0.05)。脑电β波占比及FTT-β频带功率与P3b潜伏期呈正相关(r=0.483、0.517,P<0.05);脑电β波占比及FTT-β频带功率与P3b波幅呈负相关(r=-0.540、-0.691,P<0.01)。结论失眠病人脑电β波及FTT-β频带功率增加,事件相关电位P300改变,这可为评估失眠引起脑功能改变及认知功能障碍提供客观依据。Objective To investigate the correlation of brain wave and electroencephalography(EEG)band power with event-related potential P300 in patients with primary insomnia,and to provide an objective basis for evaluating the impact of primary insomnia on brain function and cognitive function.Methods A total of 31 patients with primary insomnia were enrolled as subjects(insomnia group),and 31 healthy adults were enrolled as control group.Routine EEG monitoring and event-related potential P300(P3a and P3b)examination were performed for both groups to investigate the proportion of brain waves,EEG band po-wer,and the latency and amplitude of P3a and P3b,and a correlation analysis was performed.Results There were significant differences between the insomnia group and the control group in the latency and amplitude of P3a and P3b,the proportion of EEGαwave and EEGβwave,FTT-βfrequency power,and FTT-total frequency power(Z=-6.84 to-1.99,P<0.05).The proportion of EEGβwave and FTT-βfrequency power were positively correlated with P3b latency(r=0.483,0.517;P<0.05)and were negatively correlated with P3b amplitude(r=-0.540,-0.691;P<0.01).Conclusion There are increases in EEGβwaves and FTT-βfrequency power in patients with insomnia,along with the changes in event-related potential P300,which can provide an objective basis for evaluating the brain function alterations and cognitive impairment caused by insomnia.

关 键 词：入睡和睡眠障碍 脑电波 脑地形图 事件相关电位 P300 认知功能障碍 

分 类 号：R741.044[医药卫生—神经病学与精神病学]