肺癌胸腔镜术后肺部感染危险因素及血清Cit H3、TREM-1早期预测术后肺部感染的价值  

Risk factors of pulmonary infection after thoracoscopic surgery for lung cancer and the value of serum Cit H3 and TREM⁃1 in early prediction of postoperative pulmonary infection

作　　者：侯保超 曹险峰 HOU Baochao;CAO Xianfeng(Department of Cardiothoracic Surgery,the First People’s Hospital of Mengcheng County,Bozhou,Anhui,China,233500)

机构地区：[1]安徽省蒙城县第一人民医院胸心外科,安徽亳州233500

出　　处：《分子诊断与治疗杂志》2024年第7期1212-1215,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省自然科学项目(2108085QC86)。

摘　　要：目的 探讨肺癌胸腔镜术后肺部感染危险因素及血清瓜氨酸化组蛋白H3(Cit H3)、髓细胞上表达的触发受体1(TREM-1)早期预测术后肺部感染的价值。方法 选取2020年7月至2023年7月安徽省蒙城县第一人民医院肺癌胸腔镜手术患者89例,统计术后肺部感染发生情况,采用Logistic回归分析肺部感染危险因素,采用受试者工作特征(ROC)分析血清Cit H3、TREM-1水平对肺部感染的预测价值。结果 89例肺癌胸腔镜手术患者术后共18例出现肺部感染,发生率为20.45%(18/88);Logistic回归分析显示,年龄、吸烟指数、术前FEV1%、病理分期、手术时间及术前血清Cit H3、TREM-1水平均为肺癌胸腔镜术后肺部感染影响因素(P<0.05);ROC曲线显示,Cit H3、TREM-1联合预测肺癌胸腔镜术后肺部感染的AUC值0.715最大,对应敏感度为0.814,特异度为0.828。结论 肺癌胸腔镜术后肺部感染率较高,联合检测Cit H3、TREM-1有助于提高对胸腔镜术后肺部感染的诊断价值。Objective To investigate the risk factors of lung infection after thoracoscopic surgery for lung cancer and the value of serum citrolinated histone H3(Cit H3)and trigger receptor 1(TREM-1)ex-pressed on myeloid cells in early prediction of lung infection.Methods From July 2020 to July 2023,89 pa-tients with lung cancer undergoing thoracoscopic surgery at the First People’s Hospital of Mengcheng County,Anhui Province were selected.The incidence of postoperative lung infections was statistically analyzed,and the risk factors of lung infections were analyzed using logistic regression.The predictive value of serum Cit H3 and TREM-1 levels in pulmonary infection was analyzed using receiver operating characteristic(ROC)curves.Results A total of 18 out 89 patients with lung cancer who underwent thoracoscopic surgery had pulmonary in-fections,resulting in an incidence rate of 20.45%(18/88).Logistic regression analysis showed that age,smok-ing index,preoperative FEV1%,pathological stage,operation time and preoperative serum Cit H3 and TREM-1 levels were all influencing factors for lung cancer infection after thoracoscopic surgery(P<0.05).The ROC curve showed that Cit H3 and TREM-1 combined prediction of lung cancer thoracoscopic postoperative lung in-fection had the largest AUC value of 0.715,with a corresponding sensitivity of 0.814,and specificity of 0.828.Conclusion The rate of lung infection after thoracoscopic surgery is high.The combined detection of Cit H3 and TREM-1 is helpful in improving the diagnostic value of lung infection following thoracoscopic surgery.

关 键 词：肺癌 胸腔镜手术 瓜氨酸化组蛋白H3 髓细胞上表达的触发受体1 

分 类 号：R734.2[医药卫生—肿瘤]