血清ChE、CysC、NLR与急性脑梗死严重程度和预后的相关性  

Correlation of serum ChE,CysC,NLR with severity and prognosis of acute cerebral infarction

作　　者：卞熠 周文生 纪勇顺 张雅晴 杜龙舟 BIAN Yi;ZHOU Wensheng;JI Yongshun;ZHANG Yaqing;DU Longzhou(Department of Neurology,the Eighth People’s Hospital of Hefei,Hefei,Anhui,China,238000;Department of Clinical Laboratory,the Eighth People’s Hospital of Hefei,Hefei,Anhui,China,238000)

机构地区：[1]合肥市第八人民医院检验科,安徽合肥238000 [2]合肥市第八人民医院神经内科,安徽合肥238000

出　　处：《分子诊断与治疗杂志》2024年第7期1285-1288,1293,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康委科研项目(AHWJ2021b034)。

摘　　要：目的 探究血清胆碱酯酶(ChE)、胱抑素C(CysC)、中性粒细胞与淋巴细胞比值(NLR)与急性脑梗死(ACI)患者病情严重程度及预后的相关性。方法 分析2018年1月至2023年7月合肥市第八人民医院收治的ACI患者资料105例,根据美国国立卫生研究院脑卒中量表(NIHSS)评分、出院后随访6个月改良Rankin量表(mRS)评分进行分组。比较各组基线资料、血清相关指标差异;分析血清ChE、CysC、NLR与NIHSS、mRS评分的关系以及血清ChE、CysC、NLR对ACI患者预后的预测价值。结果 预后不良组患者合并糖尿病占比、合并高脂血症占比、年龄、入院时NIHSS评分、血清CysC、NLR水平均高于预后良好组(χ^(2)=8.653、12.083,t=4.832、8.364、5.350、6.512,P<0.05),血清ChE水平低于预后良好组(t=5.651,P<0.05);患者血清ChE水平随病情加重逐渐下降,CysC、NLR水平随病情加重逐渐上升,差异具有统计学意义(F=19.203、6.755、20.154,P<0.05);血清ChE、CysC、NLR水平与入院时NIHSS评分和随访6月mRS评分具有相关性(r=-0.623、-0.551、0.526、0.581、0.613、0.649,均P<0.05);ROC曲线结果显示血清ChE、CysC、NLR单独检测的曲线下面积(AUC)分别为0.861、0.777、0.824,三者联合检测的AUC为0.940。结论 ACI患者血清ChE、CysC、NLR水平与其病情及预后具有良好相关性,ChE水平越低、CysC、NLR水平越高,患者病情越严重,三者联合检测对ACI患者预后具有良好预测价值。Objective To explore the correlation between serum cholinesterase(ChE),cystatin C(CysC),neutrophil to lymphocyte ratio(NLR)and the severity and prognosis of acute cerebral infarction(ACI)patients.Methods Data from 105 ACI patients admitted to the Eighth People's Hospital of Hefei from January 2018 to July 2023 were retrospectively analyzed.The patients were grouped based on their National Institutes of Health Stroke Scale(NIHSS)and Modified Rankin Scale(mRS)scores after 6 months of follow-up post-discharge.Differences in baseline data and serum related indicators were compared among the groups.The relationship between serum ChE,CysC,NLR,NIHSS,and mRS scores,and the predictive value of serum ChE,CysC,and NLR on the prognosis of ACI patients,were analyzed.Results The proportion of patients with diabetes mellitus,hyperlipidemia,older age,higher NIHSS score at admission,and elevated serum CysC and NLR levels in the poor prognosis group were all significantly higher compared to those in the good prognosis group(χ^(2)=8.653,12.083,t=4.832,8.364,5.350,6.512,P<0.05).Converely,the level of ChE in serum was lower in the poor prognosis group than in the good prognosis group(t=5.651,P<0.05).The levels of ChE and CysC and NLR in serum decreased progressively as the disease worsened with statistically significant differences observed(F=19.203,6.755,20.154,P<0.05).Serum levels of ChE,CysC,and NLR were found to be correlated with both NIHSS score at admission and mRS score at 6 months of follow-up(r=-0.623,-0.551,0.526,0.581,0.613,0.649,P<0.05).ROC curve results showed that the area under the curve(AUC)for ChE,CysC and NLR individually were 0.861,0.777 and 0.824,respectively.When combined,the AUC of the detection was 0.940.Conclusion The levels of ChE,CysC,and NLR in the serum of ACI patients have a strong correlation with their disease and prognosis.Patients with lower levels of ChE,higher levels of CysC,and NLR tend to have more severe disease.The combined detection of these three markers has a high predictive value for the p

关 键 词：急性脑梗死 血清胆碱酯酶 胱抑素C 中性粒细胞与淋巴细胞比值 

分 类 号：R743.33[医药卫生—神经病学与精神病学]