封闭负压引流在口腔颌面间隙感染患者中的应用效果及对IL-6、5-HT、NPY水平影响  

Application of closed negative pressure drainage and its effect on IL⁃6,5⁃HT,NPY levels in patients with oral and maxillofacial space infection

作　　者：郭晓峰 孙岳祥 张翠芬 杜艳锋 郑洋 GUO Xiaofeng;SUN Yuexiang;ZHANG Cuifen;DU Yanfeng;ZHENG Yang(Department of Orthodontics,Handan Stomatological Hospital,Handan,Hebei,China,056001;Department of Prosthetics,Handan Stomatological Hospital,Handan,Hebei,China,056001)

机构地区：[1]邯郸市口腔医院正畸科,河北邯郸056001 [2]邯郸市口腔医院修复科,河北邯郸056001

出　　处：《分子诊断与治疗杂志》2024年第7期1307-1310,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河北省医学科学研究课题计划(20191815)。

摘　　要：目的 探究封闭负压引流(VSD)在口腔颌面间隙感染患者中的应用效果及对IL-6、5-HT、NPY水平的影响。方法 选取2019年3月至2023年7月期间邯郸市口腔医院收治的口腔颌面间隙感染患者121例,并根据引流方式的差异将其分为对照组(采用切口引流,n=60例)与观察组(予以VSD,n=61例)。对比两组临床疗效、治疗情况、白介素-6(IL-6)、5-羟色胺(5-HT)、神经肽Y(NPY)水平、疼痛程度以及术后感染情况。结果 观察组(98.36%)的总有效率明显高于对照组(88.33%),差异有统计学意义(P<0.05);观察组术后瘢痕长度、住院时间短于对照组,张口受限缓解值高于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、5-HT、NPY水平、VAS评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组术后感染总发生率比较,差异无统计学意义(P>0.05)。结论 应用VSD治疗口腔颌面间隙感染患者的临床疗效佳,可有效改善炎症反应、疼痛程度以及美观度,值得临床推广应用。Objective To explore the application of closed negative pressure drainage and its ef-fect on IL-6,5-HT,NPY levels in patients with oral and maxillofacial space infection.Methods We retro-spectively analyzed 121 patients with oral and maxillofacial gap infections who were admitted to Handan Sto-matological Hospital during the period of March 2019-July 2023 and divided them into the control group(with incisional drainage,n=60 cases)and the observation group(with VSD,n=61 cases)according to the differ-ences in drainage methods.The two groups were compared in terms of clinical efficacy,treatment,interleukin 6(IL-6),5-hydroxytryptamine(5-HT),neuropeptide Y(NPY)levels,pain level and postoperative infections.Results The total effective rate of the observation group(98.36%)was significantly higher than that of the control group(88.33%),the difference was statistically significant(P<0.05).The postoperative scar length and hospital stay of the observation group were shorter than that of the control group,and the relief value of the mouth opening restriction was higher than that of the control group,the difference was statistically signifi-cant(P<0.05).After treatment,the levels of IL-6,5-HT,NPY,and VAS scores of botj groups were re-duced,awith lower levels in the observation group.The difference was statistically significant(P<0.05).Com-paring the total incidence of postoperative infection between the two groups,the difference was not statistically significant(P>0.05).Conclusion The clinical efficacy of applying VSD to treat patients with oral and maxil-lofacial gap infections is high.This treatment can effectively improve the inflammatory response,reduce pain levels and enhance aesthetics.Therefore,it is worthy of clinical promotion and application.

关 键 词：封闭负压引流 切口引流 口腔颌面间隙感染 IL-6 5-HT NPY 美观度 

分 类 号：R782.3[医药卫生—口腔医学]