根治性子宫切除术结合盆腔淋巴结清扫术对宫颈癌患者血清CA-199、CA125、SCC-Ag水平的影响  

Effect of radical hysterectomy combined with pelvic lymph node dissection on serum CA⁃199,CA125,and SCC⁃Ag levels in patients with cervical cancer

作　　者：许曼 李宣 杨方磊 江飞云[1] XU Man;LI Xuan;YANG Fangei;JIANG Feiyun(Department of Gynecology,the Second People’s Hospital of Wuhu City,Wuhu,Anhui,China,241000)

机构地区：[1]安徽省芜湖市第二人民医院妇科,安徽芜湖241000

出　　处：《分子诊断与治疗杂志》2024年第7期1320-1323,共4页Journal of Molecular Diagnostics and Therapy

基　　金：芜湖市卫健委科研项目(WHWJ2021ly028)。

摘　　要：目的 探讨根治性子宫切除术结合盆腔淋巴结清扫术应用于宫颈癌患者的效果及对患者血清肿瘤标志物糖类抗原199(CA199)、糖类抗原125(CA125)、鳞状上皮细胞癌抗原(SCC-Ag)水平的影响。方法 选取2018年1月至2023年6月期间于芜湖市第二人民医院接受手术治疗的118例宫颈癌患者资料,根据手术方式不同分为传统开腹组(42例,接受传统开腹根治性子宫切除术)和微创组(76例,接受腹腔镜下根治性子宫切除术联合盆腔淋巴结清扫术),比较两组手术效果及患者血清肿瘤标志物水平差异。结果 微创组手术时间较开腹组更长,术中出血量较开腹组少,住院时间、胃肠道恢复时间短于开腹组,差异均有统计学意义(t=6.881、12.348、21.622、11.780,P<0.05);与术前比较,术后两组血清CA-199、CA125、SCC-Ag水平均下降:术前>术后2周>术后1月,微创组术后各时间点上述指标水平均低于开腹组,差异有统计学意义(F=237.516、8.733、6.182、251.616、12.520、7.069、250.512、14.554、4.663,P<0.05);微创组术后并发症总发生率低于开腹组,差异有统计学意义(χ^(2)=4.116,P<0.05)。结论 腹腔镜下根治性子宫切除术结合盆腔淋巴结清扫术治疗宫颈癌,可以优化手术效果,促进术后康复,提高安全性,改善预后。Objective To investigate the effect of radical hysterectomy combined with pelvic lymph node dissection and the effects on the levels of serum tumor markers[carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCC-Ag)]in patients with cervical cancer.Methods Data from 118 patients with cervical cancer who underwent surgical treatment at the Second People’s Hospital of Wuhu City from January 2018 to June 2023 were retrospectively analyzed.The patients were divided into two groups based on their surgical plan,42 patients were classified into the tradi-tional laparotomy group and underwent traditional radical hysterectomy,while 76 cases were included in the minimally invasive group and underwent laparoscopic radical hysterectomy combined with pelvic lymph node dissection.The surgical outcomes and serum tumor markers were compared between the two groups.Results The operation time for the minimally invasive group was longer than that of the traditional laparotomy group,but the amount of intraoperative blood loss was less.The hospital stay and gastrointestinal recovery time were shorter than that of the traditional laparotomy group,the differences were statistically significant(t=6.881,12.348,21.622,11.780,P<0.05).Compared with pre-operation levels,the serum CA-199,CA125,and SCC-Ag levels in both groups decreased after surgery:before surgery>2 weeks after surgery>1 month after surgery.Furthermore,the levels of these indices in the minimally invasive group were condidtently lower than those in the laparotomy group at all time points after surgery(F=237.516,8.733,6.182,251.616,12.520,7.069,250.512,14.554,4.663,P<0.05).The total incidence of postoperative complications in the minimally invasive group was lower than that in the traditional laparotomy group,and the difference was statistically sig-nificant(χ^(2)=4.116,P<0.05).Conclusion Laparoscopic radical hysterectomy,combined with pelvic lymph node dissection in the treatment of cervical cancer,can optimize surgical outcomes,p

关 键 词：宫颈癌 根治性子宫切除术 盆腔淋巴结清扫术 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]