HIV合并宫颈癌患者采用单纯放疗和同步放化疗的疗效及毒副作用分析  

Curative Effect and Toxic Side Effect Analysis of Simple Radiotherapy and Synchronous Radiotherapy and Chemotherapy for HIV Patients with Cervical Cancer

作　　者：蒋林君 薛斌跃 张蓉 JIANG Linjun;XUE Binyue;ZHANG Rong(Oncology Department No.3,Sichuan Friendship Hospital,Chengdu,Sichuan 610000)

机构地区：[1]四川友谊医院肿瘤三科,四川成都610000

出　　处：《智慧健康》2024年第17期76-79,共4页Smart Healthcare

基　　金：2022年成都市医学科研课题项目《HIV合并宫颈恶性肿瘤的放疗疗效及毒副作用分析》(项目编号:2022453)。

摘　　要：目的探讨HIV合并宫颈癌患者采用单纯放疗和同步放化疗的疗效及毒副作用分析。方法将2018年1月—2022年12月在本院治疗的62例HIV合并宫颈癌患者随机分为两组,对照组使用单纯放疗,观察组使用同步放化疗,对比两组的近期疗效、毒副反应、肿瘤标志物、免疫功能指标。结果观察组治疗有效率、临床控制率明显高于对照组,组间差异有统计学意义(P<0.05)。观察组恶心呕吐、白细胞减少、血小板减少等毒副反应发生率高于对照组,组间差异有统计学意义(P<0.05);而两组肾功能损害、放射性膀胱炎、放射性肠炎发生率相当,差异无统计学意义(P>0.05)。观察组治疗后CEA、CA12-5、SCC-Ag水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组治疗后CD3+、CD3+和CD4+、CD3+和CD8+、NK细胞均与对照组相当,差异无统计学意义(P>0.05)。结论HIV合并宫颈癌患者采用同步放化疗的疗效更好,能有效降低肿瘤标志物水平,对免疫功能影响小,胃肠道及骨髓抑制毒副反应发生率较高,但整体可耐受。Objective To explore effect and toxic side effect of simple radiotherapy and synchronous radiotherapy and chemotherapy for HIV patients with cervical cancer.Methods The paper chose 62 HIV patients with cervical cancer in our hospital from January 2018 to December 2022,and divided them into two groups randomly.Control group was treated with simple radiotherapy,while observation group with synchronous radiotherapy and chemotherapy.Recent effect,toxicity,tumor markers,and immune function indicators were compared between two groups.Results Effective rate and clinical control rate of observation group was significantly higher than control group(P<0.05).Incidence of toxic side effect including nausea,vomiting,leukopenia,and thrombocytopenia in observation group was higher than control group,while incidence of renal function damage,radiation cystitis,and radiation enteritis between two groups was comparable(P>0.05).Levels of CEA,CA125,and SCC-Ag in observation group were lower than control group after treatment(P<0.05).After treatment,the CD3+,CD3+,CD4+,CD3+,CD8+,and NK cells in observation group were comparable to control group(P>0.05).Conclusion Synchronous radiotherapy and chemotherapy is effective for HIV patients with cervical cancer,can reduce tumor marker levels effectively,with little effect on immune function and higher incidence of gastrointestinal and bone marrow suppression toxic side effect,which is generally tolerable.

关 键 词：HIV 宫颈癌 单纯放疗 同步放化疗 疗效 毒副作用 

分 类 号：R737.33[医药卫生—肿瘤] R512.91[医药卫生—临床医学]