血清淀粉酶、CA19-9、CA12-5及HE4联合检测在卵巢浆液性腺癌中的价值评价  

Value Evaluation of Combined Detection of Serum Amylase,CA19-9,CA12-5 and HE4 for Ovarian Serous Adenocarcinoma

作　　者：侯雅丽 HOU Yali(Laboratory Department,Shenzhen Hezheng Hospital,Shenzhen,Guangdong 518129)

机构地区：[1]深圳禾正医院检验科,广东深圳518129

出　　处：《智慧健康》2024年第13期59-61,共3页Smart Healthcare

摘　　要：目的探讨血清淀粉酶、CA19-9、人附睾蛋白(HE)4、CA12-5联合检测在卵巢浆液性腺癌中的价值。方法选取2020年11月—2021年10月本院收治的49例卵巢浆液性腺癌患者为病例组,52例卵巢良性疾病患者为良性病变组,63例同期接受健康体检的女性为健康组,均接受血清淀粉酶、CA19-9、CA12-5及HE4检查。分析上述肿瘤标志物单独或联合检测对卵巢浆液性腺癌的诊断价值。结果病例组CA12-5、HE4、血清淀粉酶、CA19-9水平高于良性病变组和健康组,组间对比差异有统计学意义(P<0.05);病例组CA12-5、HE4、CA19-9、血清淀粉酶阳性率高于良性病变组和健康组,组间对比差异有统计学意义(P<0.05);HE4、CA12-5、血清淀粉酶、CA19-9联合检测诊断符合率、敏感度、特异度均高于单独检测,组间对比差异有统计学意义(P<0.05)。结论血清淀粉酶、CA19-9、CA12-5及HE4均在卵巢浆液性腺癌中表达,且联合检测诊断价值较单独检测更高。Objective To explore value of combined detection of serum amylase,CA19-9,human epididymal protein(HE)4 and carbohydrate antigen CA12-5 for ovarian serous adenocarcinoma.Methods The paper chose 49 patients with ovarian serous adenocarcinoma in our hospital from November 2020 to October 2021 as case group,52 patients with benign ovarian diseases as lesion group,and 63 women with health examinations during the same period as healthy group,all treated with serum amylase,CA19-9,CA12-5,and HE4 detection.Diagnostic value of above tumor markers only or in combination for ovarian serous adenocarcinoma was analyzed.Results Levels of CA12-5,HE4,serum amylase,CA19-9 in case group were higher than in benign lesion group in healthy group.There was significant difference between the groups(P<0.05).Positive rates of CA12-5,HE4 CA19-9 and serum amylase in case group were higher than in benign lesion group,in healthy group,(P<0.05).Combined diagnostic accuracy,sensitivity and specificity of HE4,CA12-5 and serum amylase and CA19-9 were higher than single detection of CA12-5,including accuracy,sensitivity and specificity,single detection of HE4 single detection of CA19-9 and single detection of serum amylase(P<0.05).Conclusion Serum amylase,CA19-9,CA12-5 and HE4 all express in ovarian serous adenocarcinoma,and combined detection can achieve higher diagnostic value than single detection.

关 键 词：卵巢浆液性腺癌 血清淀粉酶 CA12-5 HE4 

分 类 号：R737.31[医药卫生—肿瘤]