牛碱性成纤维细胞生长因子联合子宫颈LEEP治疗子宫颈鳞状上皮内病变的临床观察  

Clinical Observation of Bovine Basic Fibroblast Growth Factor Combined with Cervical LEEP in the Treatment of Cervical Squamous Intraepithelial Lesion

作　　者：罗琦 万和平[1] LUO Qi;WAN Heping(Department of Obstetrics and Gynecology,First People's Hospital of Fuzhou,Fuzhou 344000,China;不详)

机构地区：[1]抚州市第一人民医院妇产科,江西抚州344000

出　　处：《中国医学创新》2024年第20期27-30,共4页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(20192594)。

摘　　要：目的:探究子宫颈鳞状上皮内病变(SIL)应用牛碱性成纤维细胞生长因子(bFGF)联合子宫颈环形电切术(LEEP)治疗的效果。方法:采用随机数字表法将2021年1月—2023年8月抚州市第一人民医院收治的80例SIL患者分为研究组(n=40)及对照组(n=40)。对照组采用子宫颈LEEP治疗,研究组予以子宫颈LEEP联合bFGF治疗。对比两组临床疗效、创面愈合情况、炎症因子水平及并发症发生情况。结果:相比于对照组(77.50%),研究组治疗总有效率(97.50%)高,差异有统计学意义(P<0.05)。相比于对照组,研究组阴道出血量少,阴道出血持续时间和阴道流液时间均短,术后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)水平均低,差异均有统计学意义(P<0.05)。相比于对照组(17.50%),研究组并发症发生率(2.50%)低,差异有统计学意义(P<0.05)。结论:SIL患者应用bFGF联合子宫颈LEEP治疗,效果显著,有助于促进创面愈合,并可降低炎症因子水平和并发症发生率,安全性较高。Objective:To investigate the effect of bovine basic fibroblast growth factor(bFGF)combined with loop electrosurgical excision procedure(LEEP)of cervix in the treatment of cervical squamous intraepithelial lesion(SIL).Method:A total of 80 patients with SIL admitted to First People's Hospital of Fuzhou from January 2021 to August 2023 were divided into study group(n=40)and control group(n=40)by random number table method.The control group was treated with carvical LEEP,and the study group was treated with carvical LEEP combined with bFGF.The clinical efficacy,wound healing,inflammatory factors levels and complications were compared between the two groups.Result:Compared with the control group(77.50%),the total effective rate of the study group(97.50%)was higher,the difference was statistically significant(P<0.05).Compared with the control group,the amount of vaginal bleeding in the study group was less,the duration of vaginal bleeding and vaginal fluid flow time were shorter,and the levels of C reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)after surgery were lower,the differences were statistically significant(P<0.05).Compared with the control group(17.50%),the complication rate of the study group(2.50%)was lower,the difference was statistically significant(P<0.05).Conclusion:The treatment of SIL patients with bFGF combined with carvical LEEP has a significant effect,which is helpful to promote wound healing,reduce the levels of inflammatory factors and the incidence of complications,and has high safety.

关 键 词：子宫颈鳞状上皮内病变 牛碱性成纤维细胞生长因子 子宫颈环形电切术 并发症 

分 类 号：R737.33[医药卫生—肿瘤]