益气养阴法联合二甲双胍在NAFLD的治疗中对胰岛素抵抗及胰岛素样生长因子-1的影响  

Effects of Benefiting Qi and Nourishing Yin Method Combined with Metformin on Insulin Resistance and Insulin-like Growth Factor-1 in the Treatment of NAFLD

作　　者：石磬 吴刚[1] 张宇 SHI Qing;WU Gang;ZHANG Yu(不详;Department of Hepatology,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China)

机构地区：[1]九江市第一人民医院肝病科,江西九江332000

出　　处：《中国医学创新》2024年第21期19-23,共5页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202311476)。

摘　　要：目的:探究益气养阴法联合二甲双胍在非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)治疗中对胰岛素抵抗及胰岛素样生长因子-1(IGF-1)的影响。方法:选择2022年1月—2023年8月在九江市第一人民医院就诊的NAFLD患者80例作为研究对象,按照随机数字表法将其分为试验组(n=40)与对照组(n=40)。对照组采用二甲双胍治疗,试验组采用二甲双胍联合益气养阴法治疗,两组均治疗8周。对比两组临床疗效、血脂水平、肝功能指标、胰岛素抵抗、IGF-1。结果:试验组治疗总有效率高于对照组(χ^(2)=6.275,P=0.012);治疗后,两组总胆固醇(TC)、甘油三酯(TG)水平均较治疗前降低,试验组TC、TG均低于对照组(P<0.05);治疗后,两组γ-谷氨酰转移酶(γ-GT)、天门冬氨酸氨基转移酶(AST)水平均较治疗降低,试验组γ-GT、AST均低于对照组(P<0.05);治疗后,两组胰岛素抵抗均较治疗前降低,IGF-1水平均升高,试验组胰岛素抵抗低于对照组,IGF-1水平高于对照组(P<0.05)。结论:益气养阴法联合二甲双胍治疗NAFLD能改善患者血脂水平、肝功能和胰岛素抵抗,提高治疗效果。Objective:To explore the effects of benefiting Qi and nourishing Yin method combined with Metformin on insulin resistance and insulin-like growth factor-1(IGF-1)in the treatment of non-alcoholic fatty liver disease(NAFLD).Method:A total of 80 patients with NAFLD who were treated in Jiujiang NO.1 People's Hospital from January 2022 to August 2023 were selected as the study objects,and they were divided into experimental group(n=40)and control group(n=40)according to random number table method.The control group was treated with Metformin,and the experimental group was treated with Metformin combined with benefiting Qi and nourishing Yin method.Both groups were treated for 8 weeks.The clinical efficacy,blood lipid levels,liver function indexes,insulin resistance and IGF-1 were compared between the two groups.Result:The total effective rate of experimental group was higher than that of control group(χ^(2)=6.275,P=0.012).After treatment,total cholesterol(TC)and triglyceride(TG)levels in both groups were lower than those before treatment,and TC and TG levels in experimental group were lower than those in control group(P<0.05).After treatment,the levels ofγ-glutamyltransferase(γ-GT)and aspartate aminotransferase(AST)in both groups were lower than those before treatment,andγ-GT and AST levels in experimental group were lower than those in control group(P<0.05).After treatment,insulin resistance were decreased and IGF-1 levels were increased in both groups compared with those before treatment,insulin resistance in experimental group was lower than that in control group,IGF-1 level was higher than that in control group(P<0.05).Conclusion:Benefiting Qi and nourishing Yin method combined with Metformin can improve blood lipid levels,liver function and insulin resistance in patients with NAFLD,and improve the therapeutic effect.

关 键 词：非酒精性脂肪性肝病 益气养阴法 二甲双胍 胰岛素抵抗 胰岛素样生长因子-1 

分 类 号：R575.5[医药卫生—消化系统]