盐酸川芎嗪注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果  

Effects of Ligustrazine hydrochloride injection combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction

作　　者：万志妮 WAN Zhini(Department of Internal Medicine of Yan’an Baota District People’s Hospital,Yan’an 716000 Shaanxi,China)

机构地区：[1]延安市宝塔区人民医院内科,陕西延安716000

出　　处：《中国民康医学》2024年第15期109-111,115,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察盐酸川芎嗪注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者的效果。方法:选取2023年1—12月该院收治的98例急性脑梗死患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各49例。对照组采用阿替普酶静脉溶栓治疗,观察组在对照组基础上联合盐酸川芎嗪注射液治疗,比较两组临床疗效、脑血流动力学指标水平、血清神经因子[神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)、神经胶质纤维酸性蛋白(GFAP)、神经生长因子(NGF)]水平、血清血管内皮功能指标[血栓素B_(2)(TXB_(2))、血管内皮生长因子(VEGF)、可溶性细胞间黏附分子-1(sICAM-1)、一氧化氮(NO)]水平和不良反应发生率。结果:观察组治疗总有效率为97.96%,明显高于对照组的83.67%,差异有统计学意义(P<0.05);治疗后,观察组大脑前动脉、中动脉、动脉平均血流流速等脑血流动力学指标水平和血清NGF、VEGF、NO水平均高于对照组,血清NSE、MBP、GFAP、TXB_(2)、sICAM-1水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸川芎嗪注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者可提高治疗总有效率和脑血流动力学指标水平,改善血清神经因子、血管内皮功能指标水平,效果优于单纯阿替普酶静脉溶栓治疗。Objective:To observe effects of Ligustrazine hydrochloride injection combined with Alteplase intravenous thrombolysis in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 98 patients with acute cerebral infarction admitted to this hospital from January to December 2023.According to the random number table method,they were divided into observation group and control group,49 cases in each group.The control group was treated with Alteplase intravenous thrombolysis,while the observation group was treated with Ligustrazine hydrochloride injection on the basis of that of the control group.The clinical efficacy,the levels of cerebral hemodynamic indexes,serum nerve factors[neuron-specific enolase(NSE),myelin basic protein(MBP),glialfibrillary acidic protein(GFAP),nerve growth factor(NGF)]and serum vascular endothelial function indexes[thromboxane B_(2)(TXB_(2)),vascular endothelial growth factor(VEGF),soluble intercellular adhesion molecule-1(sICAM-1),nitric oxide(NO)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.96%,which was significantly higher than 83.67%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of cerebral hemodynamic indexes such as mean bloodflow velocities of anterior cerebral artery,middle cerebral artery,and posterior cerebral artery and the serum NGF,VEGF and NO levels in the observation group were higher than those in the control group,the levels of serum NSE,MBP,GFAP,TXB_(2)and sICAM-1 were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ligustrazine hydrochloride injection combined with Alteplase intravenous thrombolysis in the treatment of the patients with acute cerebral infarction can improve the total effective rate of treat

关 键 词：急性脑梗死 阿替普酶 静脉溶栓 盐酸川芎嗪 脑血流动力学 神经因子 血管内皮功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]