O-GlcNAcylation对抗癌治疗效果的影响及其机制  

Implications and mechanisms of O-GlcNAcylation on anti-cancer therapy efficacy

作　　者：马斌媛 高宏伟 尤崇革[1] 潘云燕[1] MA Bin-Yuan;GAO Hong-Wei;YOU Chong-Ge;PAN Yun-Yan(Center for Laboratory Medicine,The Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院检验医学中心,兰州730000

出　　处：《生命科学》2024年第6期818-830,共13页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(81972498);甘肃省自然科学基金项目(23JRRA1634)。

摘　　要：O-连接-N-乙酰氨基葡萄糖化(O-linkedβ-N-acetylglucosamine,O-GlcNAcylation)是蛋白质翻译后修饰(protein translation modifications,PTMs)的一种,调节各种基本的细胞生物学过程,包括基因转录、信号转导、应激反应和细胞代谢等。目前,O-GlcNAcylation对肿瘤进展的影响已被认可,但其在抗癌疗效中的作用尚未被阐明。因此,本文旨在综述失调的O-GlcNAcylation影响抗癌治疗效果的最新证据,分析O-GlcNAcylation水平失调影响抗癌疗效的几种可能的机制,讨论靶向O-GlcNAcylation作为癌症治疗增敏剂的可能性,为提高抗癌治疗效果提供理论参考。O-linkedβ-N-acetylglucosamine(O-GlcNAcylation)is one of the protein translation modifications(PTMs)that regulate a variety of fundamental cellular biological processes,including gene transcription,signal transduction,stress response and cell metabolism.The role of dysregulated O-GlcNAcylation in tumorigenesis has been recognized,but its role in the anti-cancer therapy efficacy has not been elucidated.Therefore,this article reviews the latest evidence that dysregulated O-GlcNAcylation affects anti-cancer therapy efficacy,analyzes several possible mechanisms by which dysregulated O-GlcNAcylation levels affect anti-cancer therapy efficacy,and discusses the possibility of targeting O-GlcNAcylation as a cancer therapeutic sensitizer,aiming to provide theoretical references to improve the efficacy of anti-cancer therapy.

关 键 词：O-GLCNACYLATION O-GlcNAc转移酶 抗癌治疗 耐药 化疗耐药 翻译后修饰 

分 类 号：Q71[生物学—分子生物学] R966[医药卫生—药理学]