认知行为疗法联合鲁拉西酮治疗精神分裂症的临床观察  

Clinical observation of cognitive behavior therapy combined with lurasidone in the treatment of schizophrenia

作　　者：赖忠红 钟伦淳 李红 蔡文婷 肖峰 LAI Zhonghong;ZHONG Lunchun;LI Hong;CAIWenting;XIAO Feng(Department of Psychiatry,the Third People's Hospital of Ganzhou City,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市第三人民医院精神科,江西赣州341000

出　　处：《当代医学》2024年第12期122-125,共4页Contemporary Medicine

基　　金：赣州市指导性科技计划(GZ2021ZSF24)。

摘　　要：目的探究认知行为疗法联合鲁拉西酮治疗精神分裂症的临床疗效。方法选取2021年9月至2022年12月赣州市第三人民医院收治的68例精神分裂症患者作为研究对象,随机分为实验组与对照组,每组34例。两组均接受常规化药物治疗,对照组给予鲁拉西酮治疗,实验组给予认知行为疗法联合鲁拉西酮治疗。比较两组治疗2、6个月的总有效率,治疗前后神经心理状态评价量表(RBANS)量表评分及不良反应发生情况。结果实验组治疗2、6个月总有效率分别为79.41%、94.12%,均高于对照组的55.88%、73.53%,差异有统计学意义(P<0.05)。治疗2、6个月,两组即刻记忆、视觉空间、语言、注意力及延迟记忆评分均高于前一时间点,且实验组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论认知行为疗法联合鲁拉西酮治疗精神分裂症的效果显著,能缓解精神病理,改善认知功能,安全性高。Objective To explore the clinical efficacy of cognitive behavior therapy combined with lurasidone in the treatment of schizophrenia.Methods 68 patients with schizophrenia admitted to the Third People's Hospital of Ganzhou City from September 2021 to December 2022 were se-lected as the research subjects,and they were randomly divided into the experimental group and the control group,with 34 cases in each group.Both groups were treated with conventional drugs,the control group was treated with lurasidone,while the experimental group was treated with cognitive behavioral therapy combined with lurasidone.The total response rate of the two groups at 2 and 6 months after treatment,the scores of the repeatable battery for the assessment of neuropsychological status(RBANS)before and after treatment,and the incidence of adverse reactions between the two groups were compared.Results The total effective rate in the experimental group was 79.41%and 94.12%after 2 and 6 months of treatment,respec-tively,which were higher than 55.88%and 73.53%in the control group,and the differences were statistically significant(P<0.05).After 2 and 6 months of treatment,the scores of immediate memory,visuospatial,language,attention and delayed memory of the two groups were higher than those at the previous time point,and the experimental group was higher than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.Conclusion Cognitive behavior thera-py combined with lurasidone is effective in the treatment of schizophrenia,can relieve psychopathology,improve cognitive function,and has high safety.

关 键 词：认知行为疗法 鲁拉西酮 精神分裂症 阳性和阴性症状评定量表 神经心理状态评价量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]