注射用单唾液酸四己糖神经节苷脂钠联合醒脑静注射液对脑卒中患者神经功能和炎症的影响  

Impact of monosialotetrahexosylganglioside sodium for injection combined with Xingnaojing injection on neurological function and inflammation in stroke patients

作　　者：徐颖 姚小梅 罗慧南 XU Ying;YAO Xiaomei;LUO Huinan(Gaoan Hospital of Traditional Chinese Medicine,Jiangxi Province,Gaoan 330800,China)

机构地区：[1]江西省高安市中医院,330800

出　　处：《临床合理用药杂志》2024年第24期13-16,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察注射用单唾液酸四己糖神经节苷脂钠联合醒脑静注射液对脑卒中患者神经功能和炎症的影响。方法选取2020年1月—2023年6月高安市中医院收治的62例脑卒中患者作为研究对象,按照电脑随机法分为醒脑静组31例(患者采用醒脑静注射液)和联合用药组31例(患者在醒脑静组基础上给予注射用单唾液酸四己糖神经节苷脂钠),2组患者均持续治疗1个月。比较2组临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)、简易精神状态检查量表(MMSE)、格拉斯哥昏迷量表(GCS)、改良Rankin量表(mRS)评分及实验室指标[C反应蛋白(CRP)、白介素-6(IL-6)、降钙素原(PCT)、红细胞沉降率(ESR)、中性粒细胞与淋巴细胞比值(NLR)、白细胞计数(WBC)],不良反应。结果联合用药组治疗总有效率高于醒脑静组(96.77%vs.70.97%,χ^(2)=7.631,P=0.006)。治疗1个月后,2组NIHSS、mRS评分,血清CRP、IL-6、PCT水平及ESR、NLR、WBC降低,MMSE、GCS评分升高,且联合用药组上述指标低/高于醒脑静组(P<0.01)。联合用药组与醒脑静组不良反应总发生率比较,差异无统计学意义(9.68%vs.22.58%,χ^(2)=1.908,P=0.167)。结论注射用单唾液酸四己糖神经节苷脂钠联合醒脑静注射液治疗脑卒中患者的效果显著,可有效改善神经功能,提高认知功能,减轻机体炎症,且安全性较高。Objective To observe the impact of monosialotetrahexosylganglioside sodium for injection combined with Xingnaojing injection on neurological function and inflammation in stroke patients.Methods A total of 62 cases of stroke patients admitted to Gaoan Hospital of Traditional Chinese Medicine from January 2020 to June 2023 were selected as study subjects,and they were divided into 31 cases in Xingnaojing group(patients were treated with Xingnaojing injection)and 31 cases in drug combination group(patients were given monosialotetrahexosylganglioside sodium for injection on the basis of Xingnaojing group)according to computerized randomization,and patients in the two groups were continuously treated for 1 month.Clinical efficacy,scores of NIHSS,MMSE,GCS,mRS,laboratory indexes(CRP,IL-6,PCT,ESR,NLR,WBC)before and after treatment,as well as adverse reactions were compared between the two groups.Results Total effective rate in the drug combination group was higher than that in Xingnaojing group(96.77%vs.70.97%,χ^(2)=7.631,P=0.006).Compared with those before treatment,score of NIHSS,mRS,serum levels of CRP,IL-6,PCT,and ESR,NLR,WBC after 1 month of treatment in the two groups were reduced,scores of MMSE,GCS were higher,and the indexes in the drug combination group were lower or higher than those in the Xingnaojing group(P<0.01).The difference in the total incidence of adverse reactions between the drug combination group and the Xingnaojing group was not statistically significant(9.68%vs.22.58%,χ^(2)=1.908,P=0.167).Conclusion Monosialotetrahexosylganglioside sodium for injection combined with Xingnaojing injection have an exactly clinical effect for stroke patients,it can effectively improve the neurological function and cognitive function,reduce the inflammation of the organism,and with higher safety.

关 键 词：脑卒中 注射用单唾液酸四己糖神经节苷脂钠 醒脑静注射液 神经功能 炎性因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]