益生菌联合铋剂四联对幽门螺杆菌阳性慢性胃炎患者上腹疼痛、反酸嗳气、恶心呕吐评分的影响  

Effects of probiotics combined with bismuth quadruple therapy on upper abdominal pain,sour regurgitation and belching,nausea and vomiting scores in patients with Helicobacter pylori-associated chronic gastritis

作　　者：王霞 WANG Xia(The No.2 Hospital of Baoding,Hebei,Baoding 071000,China)

机构地区：[1]河北省保定市第二医院,071000

出　　处：《河北医药》2024年第15期2312-2315,共4页Hebei Medical Journal

基　　金：保定市科学技术研究与发展计划项目(编号:2041ZF191)。

摘　　要：目的 探讨益生菌联合铋剂四联治疗幽门螺杆菌(H.pylori)阳性慢性胃炎患者对其上腹疼痛,反酸嗳气,恶心呕吐评分的影响。方法 将2020年1月至2021年6月消化内科治疗的146例幽门螺杆菌(H.pylori)阳性慢性胃炎患者随机分为2组,对照组使用铋剂四联疗法治疗,观察组使用益生菌联合铋剂四联疗法治疗,比较2组临床疗效、H.pylori根除率、症状评分、血清胃肠激素指标、血清炎性因子指标、不良反应。结果 观察组治疗有效率为94.52%,明显高于对照组的79.45%(P<0.05);观察组H.pylori根除率为87.67%,明显高于对照组的61.64%(P<0.05);观察组治疗后上腹疼痛、反酸嗳气、恶心呕吐等症状评分明显低于对照组(P<0.05);观察组治疗后血清胃蛋白酶原(PG)Ⅰ、PGⅠ/Ⅱ明显高于对照组,PGⅡ、G-17明显低于对照组(P<0.05);观察组治疗后白细胞介素-2(IL-2)、前列腺素E2(PGE2)、热休克蛋白(HSPs)水平明显高于对照组,IL-4、IL-10水平明显低于对照组(P<0.05);观察组头晕、失眠、恶心、腹胀、皮疹、腹泻、便秘等不良反应发生率明显低于对照组(P<0.05)。结论 益生菌联合铋剂四联治疗H.pylori阳性慢性胃炎的效果显著,能有效提高H.pylori根除率,缓解上腹疼痛、反酸嗳气、恶心呕吐等症状,调节血清胃肠激素水平,抑制胃黏膜炎症损伤,且能降低药物不良反应,具有积极的临床意义。Objective To explore the effects of probiotics combined with bismuth quadruple therapy(BQT) on upper abdominal pain,sour regurgitation and belching,nausea and vomiting scores in patients with Helicobacter pylori(Hp)-associated chronic gastritis.Methods A total of 146 patients with Hp-associated chronic gastritis treated in the Department of Gastroenterology of our hospital from January 2020 to June 2021 were randomly assigned into observation group(n=27) and control group(n=27).All patients were managed by BQT,and those in observation group were additionally treated with probiotics.The aim was to compare Hp eradication rate,symptom score,index of serum gastrointestinal hormone and serum inflammatory factors,as well as adverse reactions.The curative effect was assessed.Results The effective rate(94.52% vs 79.45%) and Hp eradication rate(87.67% vs 61.64%) in the observation group were significantly higher than those in the control group(both P<0.05).The symptom scores including upper abdominal pain,sour regurgitation and belching,nausea and vomiting were significantly lower in the observation group than in the control group(P<0.05).After treatment,significantly higher pepsinogen(PG)Ⅰ,PGⅠ/Ⅱ,interleukin(IL)-2,prostaglandin E2(PGE2),heat shock proteins(HSPs) and lower PGⅡ,gastrin-17(G-17),IL-4,IL-10 were found in observation group than those of control group(all P<0.05).The incidence of adverse reactions(dizziness,insomnia,nausea,bloating,rash,diarrhea,constipation) decreased notably in the observation group compared with the control group(P<0.05).Conclusion Probiotics combined with BQT has significant effects in patients with Hp-associated chronic gastritis,which can effectively improve the Hp eradication rate,relieve symptoms such as upper abdominal pain,sour regurgitation and belching,nausea and vomiting,regulate serum gastrointestinal hormone levels,inhibit gastric mucosal inflammatory damage,reduce adverse drug reactions,and with positive clinical significance.

关 键 词：慢性胃炎 幽门螺杆菌阳性 益生菌 铋剂四联疗法 疗效 症状评分 血清胃肠激素 不良反应 

分 类 号：R573.3[医药卫生—消化系统]