吡拉西坦注射液治疗脑梗死的临床效果评价  

Clinical evaluation of piracetam injection in the treatment of cerebral infarction

作　　者：沈吉康 SHEN Ji-kang(Neurology Department,Nanjing Red Cross Hospital,Nanjing 210001,China)

机构地区：[1]南京市红十字医院神经内科,210001

出　　处：《中国现代药物应用》2024年第14期77-80,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨吡拉西坦注射液治疗脑梗死的临床效果。方法选择80例脑梗死患者作为研究对象,随机分为研究组与对照组,每组40例。对照组患者实施舒血宁注射液治疗,研究组患者在对照组基础上给予吡拉西坦注射液治疗。对比两组患者治疗效果、神经功能缺损情况、不良反应发生率、炎症因子以及总体健康状况。结果研究组患者的治疗总有效率95.00%高于对照组的75.00%(P<0.05)。治疗后,研究组患者美国国立卫生研究院卒中量表(NIHSS)评分(4.47±1.25)分低于对照组的(7.32±1.16)分(P<0.05)。研究组患者不良反应总发生率7.50%低于对照组的25.00%(P<0.05)。治疗后,研究组患者白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平分别为(51.73±13.35)μg/L、(823.23±12.40)ng/L、(58.81±13.14)ng/L,均低于对照组的(62.01±13.81)μg/L、(981.88±12.41)ng/L、(77.06±13.56)ng/L(P<0.05)。治疗后,研究组患者健康调查简表(SF-36)评分(68.01±3.08)分高于对照组的(62.13±3.16)分(P<0.05)。结论对脑梗死患者实施吡拉西坦注射液治疗,可有效改善患者炎症因子水平及神经功能缺损情况,降低其不良反应发生率,治疗效果显著。Objective To explore the clinical effect of piracetam injection in the treatment of cerebral infarction.Methods 8080 patients with cerebral infarction were selected as study subjects.They were randomly divided into a study group and a control group,with 40 cases in each group.The control group was treated with Shuxuening injection,and the study group was treated with piracetam injection on the basis of control group.The treatment efficacy,neurological deficit,incidence of adverse reactions,inflammatory factors and overall health status of the two groups were compared.Results The total effective rate of treatment in the study group was 95.00%,which was higher than 75.00%in the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score was(4.47±1.25)points in the study group,which was lower than(7.32±1.16)points in the control group(P<0.05).The total incidence of adverse reactions in the study group was 7.50%,which was lower than 25.00%in the control group(P<0.05).After treatment,the levels of interleukin-18(IL-18),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the study group were(51.73±13.35)μg/L,(823.23±12.40)ng/L,and(58.81±13.14)ng/L,which were lower than(62.01±13.81)μg/L,(981.88±12.41)ng/L and(77.06±13.56)ng/L in the control group(P<0.05).After treatment,the 36-item short-form health survey(SF-36)score of the study group was(68.01±3.08)points,which was higher than(62.13±3.16)points of the control group(P<0.05).Conclusion The treatment piracetam injection in patients with cerebral infarction can effectively improve the levels of inflammatory factors and neurological deficits,reduce adverse reactions,and have a significant therapeutic effect.

关 键 词：吡拉西坦注射液 脑梗死 临床效果 舒血宁注射液 

分 类 号：R743.33[医药卫生—神经病学与精神病学]