从毒理学与流行病学的融合看因果推断和暴露风险评估研究  

Integration of toxicology and epidemiology:Exploring causal inference and exposure risk assessment studies

作　　者：陈婉玲 李钟意 韦丽娟 王丽君 姜岳明[1] 曾小云[1] CHEN Wanling;LI Zhongyi;WEI Lijuan;WANG Lijun;JIANG Yueming;ZENG Xiaoyun(School of Public Health,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学公共卫生学院,南宁530021

出　　处：《广西医科大学学报》2024年第7期976-981,共6页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.82204126);广西科技计划项目(No.桂科AD23026297);中国博士后科学基金资助项目(No.2023MD734153)。

摘　　要：毒理学与流行病学在探讨环境暴露与健康和疾病的关系中发挥着关键作用。然而,它们都存在固有的局限性。毒理学与流行病学相互融合,可以更全面地探索暴露与健康效应的因果关系,定量评估暴露所致的风险。本研究回顾性分析了毒理学与流行病学各自的优势和局限性,以及既往研究中两学科结合的模式,并对未来的发展方向提出思考,旨在为相关研究提供理论依据和方法学框架。Toxicology and epidemiology are both critical in exploring the relationship of environmental expo-sure with health and disease.Despite their individual limitations,integrating these two disciplines can offer a more thorough exploration of the causal relationship between exposure and health effects,as well as quantitative assessment of risks caused by exposure.This study reviews the strengths and limitations of toxicology and epide-miology and the paradigms where both disciplines have been combined in previous research,and proposes future development,aiming to provide a theoretical foundation and methodological framework for relevant studies.

关 键 词：流行病学 毒理学 Epid-Tox框架 因果推断 风险评估 

分 类 号：R99[医药卫生—毒理学]