染色质重塑:在疾病机制与治疗中的新视角  

Chromatin remodeling:new perspectives in disease mechanisms and therapy

作　　者：陈卉(综述) 王季石(审校)[1,2,3] Chen Hui;Wang Jishi(Guizhou Medical University,Guiyang 550001,China;不详)

机构地区：[1]贵州医科大学,贵阳550001 [2]贵州医科大学附属医院血液科,贵阳550004 [3]贵州省造血干细胞移植中心实验室,贵阳550005

出　　处：《疑难病杂志》2024年第8期1016-1020,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金(81960032,82170168,82370168);国家血液系统疾病临床医学研究中心转化研究课题(2021WWB01);北京白求恩公益基金委(国家级)(B19153DT);贵州省卫健委科学技术基金项目(Gzwjkj2019-2-011);贵州医科大学附属医院NSFC面上基金培育计划项目(Gyfynsfc-2021-3)。

摘　　要：染色质重塑是调节基因表达和维持基因组稳定性的关键机制。近年来,随着表观遗传学研究的深入,染色质重塑在疾病的发生、发展及其治疗中的作用受到了广泛关注。特别是在癌症、神经系统疾病和代谢疾病等疾病中,染色质重塑因子的异常活动已被证明与疾病的机制密切相关。文章对其研究进展进行综述。Chromatin remodeling is a critical mechanism for regulating gene expression and maintaining genomic stability.In recent years,with the advancement of epigenetics research,the role of chromatin remodeling in the pathogenesis,progression,and treatment of diseases has garnered widespread attention.Particularly in diseases such as cancer,neurodegenerative disorders,and developmental abnormalities,the aberrant activity of chromatin remodeling factors has been demonstrated to be closely associated with disease mechanisms.

关 键 词：染色质重塑 疾病 机制 治疗 

分 类 号：R363.2[医药卫生—病理学]