人促甲状腺激素作用机制及生物活性方法研究进展  

Research progress on the mechanism of action and bioactivity methods of human thyroid-stimulating hormone

作　　者：高婧 梁成罡[2] 李晶[2] GAO Jing;LIANG Cheng-gang;LI Jing(China Pharmaceutical University College of Life Science and Technology,Nanjing 210009,China;National Institutes for Food and Drug Control,State Key Laboratory of Drug Regulatory Science,NHC Key Laboratory of Research on Quality and Standardization of Biotech Products,Beijing 102629,China)

机构地区：[1]中国药科大学生命科学与技术学院,南京210009 [2]中国食品药品检定研究院药品监管科学全国重点实验室国家卫生健康委员会生物技术产品检定方法及其标准化重点实验室,北京102629

出　　处：《药物分析杂志》2024年第7期1105-1112,共8页Chinese Journal of Pharmaceutical Analysis

基　　金：药品监管科学全国重点实验室(2023SKLDRS0108)。

摘　　要：促甲状腺激素(thyroid-stimulating hormone,TSH)是由垂体前叶产生的糖蛋白激素。可调节甲状腺滤泡细胞中甲状腺激素的合成和分泌,具有重要生理学意义,作为药物具有重要应用价值,生物学活性检测是评价其质量的有效和必要手段,本文就促甲状腺激素的信号转导作用机理、促甲状腺激素的临床诊断与治疗、生物学活性测定方法进行论述。Thyroid-stimulating hormone(TSH)is a glycoprotein hormone produced by the anterior pituitary.It can regulate the synthesis and secretion of thyroid hormone in thyroid follicular cells,which has important physiological significance.As a drug,it has important application value.Biological activity detection is an effective and necessary to evaluate its quality.This article discusses the signal transduction mechanism of thyroid stimulating hormone,the clinical diagnosis and treatment of thyroid stimulating hormone,and the determination method of biological activity.

关 键 词：促甲状腺激素 信号转导机制 诊断与治疗 骨质疏松 甲状腺癌 多囊卵巢综合征 生物学活性测定 

分 类 号：R917[医药卫生—药物分析学]