Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment  

作　　者：Mei Zhang Jing Ma Feng-Yin Zeng Xiao-Hui Hou 

机构地区：[1]School of Preclinical Medicine,Zunyi Medical University,Zunyi 563000,Guizhou Province,China

出　　处：《World Journal of Clinical Cases》2024年第27期6094-6104,共11页世界临床病例杂志

基　　金：the Major Project of Science and Technology Foundation of Guizhou Provincial Health Commission,No.gzwkj2023-579;Zunyi Medical University Innovation Project,No.S202310661123.

摘　　要：BACKGROUND Prostate cancer(PCa)has high morbidity and mortality rates in elderly men.With a history of thousands of years,traditional Chinese medicine derived from insects could be an important source for developing cancer-targeted drugs to prevent tumorigenesis,enhance therapeutic effects,and reduce the risk of recurrence and metastasis.Multiple studies have shown that Coridius chinensis(Cc)has anticancer effects.AIM To elucidate the mechanism of action of Cc against PCa via network pharma-cology and molecular docking.METHODS Potential targets for Cc and PCa were predicted using ChemDraw 19.0 software,the PharmMapper database and the GeneCards database.Then,the STRING database was used to construct the protein–protein interaction network.Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment and molecular docking analyses were subsequently conducted to identify the key targets,active ingredients and pathways involved.RESULTS GO and KEGG analyses indicated that the PI3K-Akt signalling pathway was the critical pathway(P value<1.0×10-8).Multiple targeting ingredients that can affect multiple pathways in PCa have been identified in Cc.Seven active compounds(asponguanosines A,asponguanine B,asponguanine C,aspong-pyrazine A,N-acetyldopamine,aspongadenine B and aspongpyrazine B)were selected for molecular docking with 9 potential targets,and the results revealed that aspongpyrazine A and asponguanosine A are the main components by which Cc affects PCa(affinity<-5 kcal/mol,hydrogen bonding),but more studies are needed.CONCLUSION We used network pharmacology to predict the bioactive components and important targets of Cc for the treatment of PCa,supporting the development of Cc as a natural anticancer agent.

关 键 词：Coridius chinensis Molecular docking Network pharmacology Prostate cancer Traditional Chinese medicine 

分 类 号：R737.25[医药卫生—肿瘤]