Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies  

作　　者：Jing-Wen Liu Xiao Huang Ming-Ke Wang Ji-Shun Yang 

机构地区：[1]School of Pharmacy,Bengbu Medical University,Bengbu 233000,Anhui Province,China [2]Naval Medical Center,Naval Medical University,Shanghai 200052,China

出　　处：《World Journal of Diabetes》2024年第8期1663-1671,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Scientific Research Foundation of Shanghai Municipal Health Commission of Changning District,No.20234Y038.

摘　　要：Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased severity.Here,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 illness.The worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral uptake.Moreover,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral infections.It may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive inflammation.This review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients.

关 键 词：Diabetes mellitus SARS-CoV-2 COVID-19 SUSCEPTIBILITY Prevention Treatment 

分 类 号：R587.1[医药卫生—内分泌] R563.1[医药卫生—内科学]