Intra-articular interventions in osteoarthritis:Navigating the landscape of hyaluronic acid,mesenchymal stem cells,and plateletrich plasma  

作　　者：Somar Soufan Joenne Al Khoury Zahi Hamdan Mohamad Ali Rida 

机构地区：[1]Department of Medicine,University of Balamand,Beirut 00000,Lebanon [2]Department of Internal Medicine,Clemenceau Medical Center,Beirut 12345,Lebanon

出　　处：《World Journal of Orthopedics》2024年第8期704-712,共9页世界骨科杂志（英文版）

摘　　要：Osteoarthritis(OA)poses a substantial burden on patients,leading to pain,functional decline,and reduced quality of life.While conventional treatments focus on symptom management,disease-modifying interventions are yet to be established.This review explores the efficacy of intra-articular interventions,particularly hyaluronic acid(HA),mesenchymal stem cells(MSCs),and platelet-rich plasma(PRP),in the context of OA management.HA injections,with diverse formulations like Hylan G-F20,sodium hyaluronate,and hyaluronan,present varying outcomes,necessitating a nuanced understanding of their effectiveness and timing.MSC therapy,derived from adipose tissue,umbilical cord,or bone marrow,shows promising results in clinical improvement,with adipose-derived MSCs demonstrating efficacy in maintaining benefits over 6 mo.Conversely,bone-marrow-derived MSCs show limited effectiveness,highlighting the need for sourcespecific considerations.PRP has emerged as a superior option for long-term pain reduction and quality of life improvement,with leukocyte-poor formulations and a critical platelet count of 10 billion demonstrating optimal results.This comprehensive analysis underscores the potential of intra-articular interventions in OA management,emphasizing the need for personalized and evidence-based approaches to enhance treatment efficacy and patient outcomes.

关 键 词：Osteoarthritis Viscosupplementation PLATELETS Hyaluronic acid Stem cell 

分 类 号：R684.3[医药卫生—骨科学]