Relation between dysbiosis and inborn errors of immunity  

作　　者：Öner Özdemir 

机构地区：[1]Department of Pediatric Allergy and Immunology,Sakarya University,Medical Faculty,Adapazarı54100,Sakarya,Türkiye

出　　处：《World Journal of Methodology》2024年第4期104-109,共6页世界方法学杂志

摘　　要：Inborn errors of immunity(IEI)disorders,formerly primary immune deficiency diseases,are a heterogeneous group of disorders with variable hereditary transitions,clinical manifestations,complications and varying disease severity.Many of the clinical symptoms,signs and complications in IEI patients can be attributed to inflammatory and immune dysregulatory processes due to loss of microbial diversity(dysbiosis).For example,in common variable immunodeficiency patients,the diversity of bacteria,but not fungi,in the gut microbiota has been found to be reduced and significantly altered.Again,this was associated with a more severe disease phenotype.Compromise of the STAT3/Th17 pathway in hyper-IgE syndrome may lead to dysbiosis of the oral microbiota in these patients,causing Candida albicans to switch from commensal to pathogenic.Modification of the microbiota can be used as a therapeutic approach in patients with IEI.Prebiotics,probiotics,postbiotics and fecal microbiota transplantation can be used to restore the balance of the gut microbiota and reduce pathogenicity in IEI patients.Clinical trials are currently underway to understand the impact of this dysbiosis on the phenotype of IEI diseases and its role in their treatment.

关 键 词：IMMUNODEFICIENCY MICROBIOME MICROBIOTA Fecal microbiota transplantation IMMUNOGLOBULIN 

分 类 号：R378[医药卫生—病原生物学]