Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan  

作　　者：Fan Zeng Da-Ya Zhang Shi-Ju Chen Run-Xiang Chen Chen Chen Shi-Mei Huang Da Li Xiao-Dong Zhang Jia-Jia Chen Cui-Yi Mo Lei Gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen Fei-Hu Bai 

机构地区：[1]Graduate School,Hainan Medical University,Haikou 571199,Hainan Province,China [2]Department of Gastroenterology,Qionghai People’s Hospital,Qionghai 571400,Hainan Province,China [3]Department of Gastroenterology,Sanya Central Hospital,Sanya 572022,Hainan Province,China [4]Department of Gastroenterology,Hainan Second People’s Hospital,Wuzhishang 572299,Hainan Province,China [5]Department of Gastroenterology,Dongfang People’s Hospital,Dongfang 572699,Hainan Province,China [6]Department of Gastroenterology,The Second Affiliated Hospital of Hainan Medical University,Haikou 570216,Hainan Province,China [7]The Gastroenterology Clinical Medical Center of Hainan Province,Haikou 570216,Hainan Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第8期3445-3456,共12页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by the Innovation Platform for Academicians of Hainan Province,No.2022136;the Specific Research Fund of the Innovation Platform for Academicians of Hainan Province,No.YSPTZX202313;Hainan Province Clinical Medical Center,No.2021818;Hainan Provincial Health Industry Research Project,No.22A200078;National Clinical Key Specialty Capacity Building Project,China,No.202330.

摘　　要：BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage diagnoses.This highlights the significance of early detection and prevention measures to enhance survival rates.Fecal immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in Hainan.AIM To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT results.METHODS This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan Province.The study was conducted from August 2022 to April 2023,employing a stratified sampling method to select participants.Individuals with positive FIT results subsequently underwent colonoscopy.Positive predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic regression.RESULTS A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT screening.The overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),respectively.Significant associations were found between age,dietary habits,and positive FIT results.Out of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance rate.Among them,10 had a clean gastrointestinal tract,43 had polyps or adenoma

关 键 词：Fecal immunochemical test Colorectal cancer ADENOMA Screening Hainan Province 

分 类 号：R735.34[医药卫生—肿瘤]