游泳短纤维鼻滴剂用于鼻脑药物传递  

Swimming short fibrous nasal drops for nose-to-brain drug delivery

作　　者：徐臆茹 丁涛 陈信良 Yiru Xu;Tao Ding;Xinliang Chen(The International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200030,China;Shanghai Key Laboratory of Embryo Original Diseases,Shanghai 200030,China;Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]The International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200030,China [2]Shanghai Key Laboratory of Embryo Original Diseases,Shanghai 200030,China [3]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《Science Bulletin》2024年第14期2153-2155,共3页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(8237060413);the Shanghai Special Project on Aging and Women’s and Children’s Health Research(2020YJZX0132)。

摘　　要：The brain,the most vital and intricate organ in the human body,governs neural activities.Homeostasis within the brain is protected by the blood–brain barrier(BBB),a unique and highly regulated semi-permeable membrane[1].Due to the BBB obstruction,traditional drug delivery methods,such as oral administration or intravenous injection,often fail to efficiently deliver drugs to the brain[2].

关 键 词：药物传递 DRUGS INJECTION 

分 类 号：R943[医药卫生—药剂学]