Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury  

作　　者：Prashasti Sharma Dharmendra Kumar Maurya 

机构地区：[1]Life Sciences,Homi Bhabha National Institute,Mumbai 400094,Maharashtra,India [2]Radiation Biology&Health Sciences Division,Bhabha Atomic Research Centre,Mumbai 400085,Maharashtra,India

出　　处：《World Journal of Stem Cells》2024年第7期742-759,共18页世界干细胞杂志（英文版）（电子版）

摘　　要：Wharton’s jelly mesenchymal stem cells(WJ-MSCs)are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation injuries.WJ-MSCs are more naïve and have a better safety profile,making them suitable for both autologous and allogeneic transplantations.This review highlights the regenerative potential of WJ-MSCs and their clinical applications in mitigating various types of radiation injuries.In this review,we will also describe why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine along with a balanced view on their strengths and weaknesses.Finally,the most updated literature related to both preclinical and clinical usage of WJ-MSCs for their potential application in the regeneration of tissues and organs will also be compiled.

关 键 词：Stem cells Wharton’s jelly mesenchymal stem cells RADIOTHERAPY XEROSTOMIA Lung fibrosis 

分 类 号：R318[医药卫生—生物医学工程]