Genitourinary tumors and liver transplantation: A comprehensive review  

作　　者：Vibor Sesa Hrvoje Silovski Nikolina Basic-Jukic Iva Kosuta Maja Sremac Anna Mrzljak 

机构地区：[1]Department of Gastroenterology and Hepatology,University Hospital Center Zagreb,Zagreb 10000,Croatia [2]Department of Hepatobiliary Surgery and Transplantation,University Hospital Center Zagreb,Zagreb 10000,Croatia [3]Department of Medicine,School of Medicine,Zagreb 10000,Croatia [4]Department of Nephrology,Arterial hypertension,Dialysis and Transplantation,University Hospital Center Zagreb,Zagreb 10000,Croatia [5]Department of Intensive Care Medicine,University Hospital Center Zagreb,Zagreb 10000,Croatia

出　　处：《World Journal of Transplantation》2024年第3期52-58,共7页世界移植杂志

摘　　要：Liver transplantation is as a crucial therapeutic option for patients with end-stage liver disease,but the persistent organ shortage emphasizes a need to explore unconventional donor sources,including individuals with a history of malignan-cies.This review investigates the viability of liver donation from individuals with current or past genitourinary malignancies,focusing on renal,prostate and urinary bladder cancers.The rising incidence of urogenital malignancies among potential donors is thought to result from increasing donor age.Analysis of transmission risks reveals low rates of donor-derived cancer transmission,partic-ularly for early-stage renal and prostate cancers.Recipients with a history of genitourinary malignancy pose complex challenges regarding post-transplant immunosuppression and cancer recurrence.Nonetheless,the evidence suggests acceptable outcomes can be achieved with careful patient selection and tailored management strategies.Recommendations for pre-transplant evaluation and post-transplant surveillance are discussed,highlighting the need for individualized approaches in this patient population.Further prospective studies are warranted to refine guidelines and optimize outcomes in liver transplantation for patients with genitourinary malignancies.

关 键 词：Liver transplantation Genitourinary malignancies Donor-transmitted cancer Malignancy recurrence IMMUNOSUPPRESSION 

分 类 号：R737[医药卫生—肿瘤] R657.3[医药卫生—临床医学]