哌嗪类新精神活性物质体内检测研究进展  

Research Progress on Detection of New Psychoactive Substance Piperazines in vivo

作　　者：刘晋廷 周莉英 相佳宏 李子怡 谢婉婷 贠克明 施妍[1] Jin-ting LIU;Li-ying ZHOU;Jia-hong XIANG;Zi-yi LI;Wan-ting XIE;Ke-ming YUN;Yan SHI(Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Ministry of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;School of Forensic Medicine,Shanxi Medical University,Jinzhong 030600,Shanxi Province,China)

机构地区：[1]司法鉴定科学研究院,上海市法医学重点实验室,司法部司法鉴定重点实验室,上海市司法鉴定专业技术服务平台,上海200063 [2]山西医科大学法医学院,山西晋中030600

出　　处：《法医学杂志》2024年第3期276-283,共8页Journal of Forensic Medicine

基　　金：国家重点研发计划资助项目(2022YFC3302003);国家自然科学基金资助项目(82271932);司法部司法鉴定重点实验室资助项目;上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目。

摘　　要：哌嗪类新精神活性物质是一类具有致幻作用的化合物,通过影响单胺能神经递质的水平进而影响中枢神经系统。滥用该类物质后,会产生刺激和致幻作用并伴头痛、头晕、焦虑、失眠、呕吐、胸痛、心动过速、高血压等不良反应,甚至可能造成心血管系统损害和多器官衰竭而死亡,严重危害身心健康和公共安全。哌嗪类新精神活性物质的滥用已引起国际社会的广泛关注,对其药理毒理及分析方法的研究成为法医学领域的研究热点。本文综述了已有的哌嗪类新精神活性物质的体内过程、样品处理以及分析方法,以期为法医学鉴定提供参考依据。Piperazines are a class of new psychoactive substances with hallucinogenic effects that affect the central nervous system by affecting the level of monoamine neurotransmitters.Abuse of piperazines will produce stimulating and hallucinogenic effects,accompanied by headache,dizziness,anxiety,insomnia,vomiting,chest pain,tachycardia,hypertension and other adverse reactions,and may even cause cardiovascular diseases and multiple organ failure and lead to death,seriously affecting human physical and mental health and public safety.The abuse of new psychoactive substance piperazines has attracted extensive attention from the international community.The study of its pharmacological toxicology and analytical methods has become a research hotspot in the field of forensic medicine.This paper reviews the in vivo processes,sample treatment and analytical methods of existing piperazines,in order to provide reference for forensic identification.

关 键 词：法医毒物化学 新精神活性物质 哌嗪类 体内过程 高效液相色谱法 气相色谱-串联质谱法 液相色谱-质谱法 综述 

分 类 号：R89[医药卫生—法医学] DF795.1[医药卫生—临床医学] D919.1[政治法律—诉讼法学]