CD146,a therapeutic target involved in cell plasticity  

作　　者：Zhenzhen Wu Yuzhe Zang Chuyi Li Zhiheng He Jingyu Liu Zhaoqi Du Xinran Ma Lin Jing Hongxia Duan Jing Feng Xiyun Yan 

机构地区：[1]CAS Engineering Laboratory for Nanozyme,Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [2]College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China [3]Nanozyme Laboratory in Zhongyuan,Henan Academy of Innovations in Medical Science,Zhengzhou 451163,China [4]Joint Laboratory of Nanozymes in Zhengzhou University,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Science China(Life Sciences)》2024年第8期1563-1578,共16页中国科学（生命科学英文版）

基　　金：supported in part by the Beijing Natural Science Foundation of China(L232077,7242092,7222117);the National Natural Science Foundation of China(82000812);the China Postdoctoral Science Foundation(2023M733682).

摘　　要：Since its identification as a marker for advanced melanoma in the 1980s,CD146 has been found to have multiple functions in both physiological and pathological processes,including embryonic development,tissue repair and regeneration,tumor progression,fibrosis disease,and inflammations.Subsequent research has revealed that CD146 is involved in various signaling pathways as a receptor or coreceptor in these processes.This correlation between CD146 and multiple diseases has sparked interest in its potential applications in diagnosis,prognosis,and targeted therapy.To better comprehend the versatile roles of CD146,we have summarized its research history and synthesized findings from numerous reports,proposing that cell plasticity serves as the underlying mechanism through which CD146 contributes to development,regeneration,and various diseases.Targeting CD146 would consequently halt cell state shifting during the onset and progression of these related diseases.Therefore,the development of therapy targeting CD146 holds significant practical value.

关 键 词：CD146 cell plasticity therapeutic target 

分 类 号：R730.5[医药卫生—肿瘤]