基于微流控的仿生细胞封装  

Biomimetic cell encapsulations by microfluidics

作　　者：王经琳 黄丹青 方壹乐 任昊桢 赵远锦 Jinglin Wang;Danqing Huang;Yile Fang;Haozhen Ren;Yuanjin Zhao(Division of Hepatobiliary and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital(The Affiliated Hospital of Nanjing University Medical School),Nanjing 210008,China;State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China)

机构地区：[1]Division of Hepatobiliary and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital(The Affiliated Hospital of Nanjing University Medical School),Nanjing 210008,China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

出　　处：《Science China Materials》2024年第8期2414-2426,共13页中国科学（材料科学）（英文版）

基　　金：supported by the National Natural Science Foundation of China(T2225003 and 82100664);the National Key Research and Development Program of China(2022YFA1105300);Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054)。

摘　　要：将细胞封装在生物材料中用于器官修复或疾病治疗是一个新兴领域.目前,微流控技术被用于精确控制封装细胞的数量、大小和支架结构.微流控技术提供了设计生物仿生形态的能力,增强封装细胞的活性和功能,从而提高疾病治疗的效果.本文报道了微流控技术在仿生细胞封装方面的最新进展.我们首先简要概述了各种天然衍生的促进细胞功能的仿生结构,如受到细胞、植物、动物和自然反应启发的结构;之后讨论了基于微技术的最新细胞封装方法,并详细描述了相关过程;最后提出了仿生细胞封装在疾病治疗和临床应用中面临的挑战和未来方向.Cell encapsulated in biomaterials for organ repair or disease treatment is indeed an emerging field.Currently,microfluidics is being utilized to precisely control the quantity,size,and scaffold structure of encapsulated cells.Specifically,microfluidics offers the ability to design biomimetic morphologies that enhance the activity and function of encapsulated cells,thereby improving the effectiveness of disease treatment.In this review,we report the latest advancements in microfluidic-based biomimetic cell encapsulation.To begin with,we provide a brief overview of various naturally derived biomimetic structures that promote cellular functionality,such as those inspired by cells,plants,animals,and natural responses.Moving forward,we discuss recent cell encapsulation methods based on microtechnology and provide detailed descriptions of the relevant processes.Finally,we address the challenges and future directions of biomimetic cell encapsulation in disease treatment and clinical applications.

关 键 词：微流控技术 封装方法 仿生结构 仿生形态 疾病治疗 未来方向 支架结构 精确控制 

分 类 号：R318[医药卫生—生物医学工程]