supported by the National Natural Science Foundation of China(T2225003 and 82100664);the National Key Research and Development Program of China(2022YFA1105300);Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054)。