仿生阳离子门控动态液膜纳米通道用于离子和分子的可控传输  

Bioinspired cation-gated dynamic liquid film nanochannel for controlled transport of ions and molecules

作　　者：梁春晓 王殿宇 何少凡 张路 夏帆 田野 Chunxiao Liang;Dianyu Wang;Shaofan He;Lu Zhang;Fan Xia;Ye Tian(Key Laboratory of Bioinspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Chemical Engineering,Zhengzhou University,Zhengzhou 450001,China;State Key Laboratory of Biogeology and Environmental Geology,Engineering Research Center of Nano-Geomaterials of Ministry of Education,Faculty of Materials Science and Chemistry,China University of Geosciences,Wuhan 430074,China;Suzhou Institute for Advanced Research,University of Science and Technology of China,Suzhou 215123,China;Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China)

机构地区：[1]Key Laboratory of Bioinspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]School of Chemical Engineering,Zhengzhou University,Zhengzhou 450001,China [4]State Key Laboratory of Biogeology and Environmental Geology,Engineering Research Center of Nano-Geomaterials of Ministry of Education,Faculty of Materials Science and Chemistry,China University of Geosciences,Wuhan 430074,China [5]Suzhou Institute for Advanced Research,University of Science and Technology of China,Suzhou 215123,China [6]Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China

出　　处：《Science China Materials》2024年第8期2523-2531,共9页中国科学（材料科学）（英文版）

基　　金：supported by the National Research Fund for Fundamental Key Projects(2019YFA070870);the National Natural Science Foundation of China(22090052,21988102);the Frontier Science Key Projects of CAS(ZDBS-LY-SLH022);the Key R&D Project of Shandong Province(2022CXGC010302)。

摘　　要：钙离子门控在生命活动中非常重要,受此启发,人工离子门控得到广泛研究.然而,传统离子门控依赖不对称电荷结构和固定通道尺寸导致通道难以堵塞和门控比低.我们构建了一种阳离子门控动态液膜纳米通道,通过将油滴插入充满离子溶液的毛细管中,利用油和毛细管之间的液膜作为纳米通道传输离子和分子,其高度可通过静电力灵活调节.门控开关依赖于离子价态.多价离子比单价离子更易降低静电斥力,从而使纳米通道从“ON”态变为“OFF”态,并显示出良好的循环门控性能和高开关比.本文提出了一种便利的智能纳米通道,仅需调节油水和水固界面之间的静电力即可调节液膜内离子和分子的传输.该技术在药物输送、生物传感和物种分离等领域具有广阔的应用前景.Calcium-gated nanochannels in vivo play an important role in many life activities.Inspired by biological ion channels,artificial ion gating has been extensively studied.However,conventional ion gating relies on asymmetric charge structures and fixed nanochannel sizes,resulting in difficult channel blocking and low gating ratios.Herein,a dynamic liquid film nanochannel is constructed by inserting an oil droplet into a carboxylated glass capillary filled with ion solution.The liquid film between the oil and capillary is used as a nanochannel to transport ions and molecules,and the height of the nanochannel can be flexibly controlled by the electrostatic force between the oil–water and water–solid interfaces.The switching of the liquid film nanochannel depends on the ion valence.Compared to monovalent ions,the introduction of multivalent ions yields less negative zeta potential at both the oil–water and water–solid interfaces,which in turn reduces the electrostatic repulsion force between the oil–water and water–solid interfaces,resulting in the nanochannel changing from the“ON”state to the“OFF”state.The system shows good cyclic gating performance and high gating ratios up to~1000.Moreover,this cation-gated liquid film nanochannel enables controlled transport of molecules such as rhodamine 6G.In this paper,we present a convenient intelligent nanochannel capable of regulating the transport of ions and molecules within the liquid film simply by adjusting the electrostatic force between the oil–water and water–solid interfaces.This research holds promise for applications in drug delivery,biosensing,species separation,and beyond.

关 键 词：纳米通道 多价离子 离子溶液 门控 静电斥力 药物输送 静电力 液膜 

分 类 号：Q811[生物学—生物工程] TB383[一般工业技术—材料科学与工程]