Expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 patients:A retrospective study  

作　　者：Elham Jafari Maskouni Samaneh Abbasi Elham Mousavi Zahra Najafimemar Ali Mohammad Arabzadeh Mehrdad Farrokhnia Saeedeh Ebrahimi 

机构地区：[1]Department of Medical Microbiology(Bacteriology&Virology),Afzalipour Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran [2]Abadan University of Medical Sciences,Abadan,Iran [3]Infectious Diseases Research Center,Golestan University of Medical Sciences,Gorgan,Iran [4]Department of Internal Medicine,Afzalipour School of Medicine,Kerman University of Medical Sciences,Kerman,Iran

出　　处：《Journal of Acute Disease》2024年第3期111-115,共5页急性病杂志（英文版）

基　　金：the research council of Kerman University of Medical Sciences,Kerman,Iran(Grant Number:400000232).

摘　　要：Objective:To explore expression level of interferon-stimulated genes PKR,OAS1,MX1,and ISG15 in peripheral blood mononuclear cells of COVID-19 patients.Methods:In this study,changes in the expression of four interferon-stimulated genes(ISGs),including PKR,OAS1,MX1,and ISG15,in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR method.Results:OAS1,MX1,PKR,and ISG15 were differently expressed in COVID-19 patients with different severity.The results showed that the expression of OAS1,MX1,PKR,and ISG15 genes was significantly(P=0.001)lower in severe patients.Conclusions:Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.

关 键 词：COVID-19 SARS-CoV-2 INTERFERON ISGs Severe COVID-19 Risk factors Interferon signaling 

分 类 号：R563.1[医药卫生—呼吸系统]