膀胱癌组织及癌旁组织中Dickkopf相关蛋白3、泛素结合酶E2T表达与患者临床病理特征、预后的关系  

Relationship between the expression of Dickkopf related protein 3 and ubiquitin-binding enzyme E2T in bladder cancer tissue and paracancer tissue with clinicopathological features and prognosis

作　　者：何露 伍庄 吕艳 He Lu;Wu Zhuang;Lyu Yan(Department of Urology,the Hua Run and Wu Gang General Hospital,Department of Urology,CR&WISCO General Hospital,Wuhan University of Science and Technology,Wuhan 430080,China)

机构地区：[1]华润武钢总医院武汉科技大学附属武钢总医院泌尿外科,武汉430080

出　　处：《中华实验外科杂志》2024年第7期1583-1587,共5页Chinese Journal of Experimental Surgery

摘　　要：目的探讨膀胱癌组织中Dickkopf相关蛋白3(DKK3)、泛素结合酶E2T(UBE2T)表达与患者临床病理特征、预后的关系。方法选取2019年2月至2021年3月73例于华润武钢总医院确诊的膀胱癌患者,以膀胱癌组织为研究组,以癌旁组织为对照组,Spearman等级相关分析膀胱癌组织中DKK3、UBE2T相关关系,影响膀胱癌患者预后的因素采用Cox回归分析,Kaplan-Meier分析DKK3、UBE2T与膀胱癌患者预后的关系。结果膀胱癌组织中DKK3阴性表达率、UBE2T阳性表达率高于癌旁组织(73.97%比50.68%、69.86%比21.92%,χ^(2)=8.430、33.790,P<0.05)。膀胱癌组织中DKK3与UBE2T为负相关,相关性系数r=-0.631、P<0.01。肿瘤直径>2cm(66.67%、66.67%)、TNM分期T2~T4(70.37%、68.63%)、淋巴结转移(68.52%、74.51%)的膀胱癌患者DKK3阴性、UBE2T阳性的表达比例高于肿瘤直径≤2cm(33.33%、33.33%)、TNM分期Ta~T1(29.63%、31.37%)、未淋巴结转移(31.48%、25.49%)的患者(χ^(2)=5.777、4.932、11.848,P<0.05)。多因素分析结果显示肿瘤直径、TNM分期、淋巴结转移、UBE2T是膀胱癌患者预后危险因素[风险比(HR)=3.750、1.972、1.166、4.679,P<0.05],DKK3(HR=0.857)是膀胱癌患者预后保护因素(P<0.05)。DKK3阴性表达患者54例存活31例,DKK3阳性表达患者19例存活17例,DKK3阴性表达患者生存率高于DKK3阴性患者(89.47%比57.41%,χ^(2)=5.073,P<0.05),UBE2T阳性表达患者51例存活29例,UBE2T阴性表达患者22例存活19例,UBE2T阴性表达患者生存率高于UBE2T阳性患者(86.36%比56.86%,χ^(2)=4.702,P<0.05)。结论膀胱癌组织中DKK3、UBE2T表达与患者临床病理特征严重程度相关,与膀胱癌患者预后密切相关。Objective To investigate the relationship between the expression of Dickkopf related protein 3(DKK3)and ubiquitin-binding enzyme E2T(UBE2T)in bladder cancer tissues and the clinico-pathological features and prognosis of patients.Methods A total of 73 patients with bladder cancer who were diagnosed in China Resources WISCOM General Hospital from February 2019 to March 2021 were se-lected.The bladder cancer tissues were taken as the study group,and adjacent tissues as the control group.Spearman rank correlation was used to analyze the correlation between DKK3 and UBE2T in bladder cancer tissue.Cox regression analysis was used to analyze the factors affecting the prognosis of bladder cancer patients.Kaplan-Meierwas used to analyze the relationship between DKK3,UBE2T with the progno-sis of bladder cancer patients.Results The negative expression rate of DKK3 and the positive expression rate of UBE2T in bladder cancer tissues were higher than those in adjacent tissues(73.97%vs.50.68%,69.86%vs.21.92%,χ^(2)=8.430,33.790,P<0.05).DKK3 and UBE2T were negatively correlated in bladder cancer tissue,with correlation coefficient r=-0.631,P<0.01.The proportions of DKK3 nega-tive expression and UBE2T positive expression in bladder cancer patients with tumor diameter>2 cm(66.67%,66.67%),TNM stage T2-T4(70.37%,68.63%),and lymph node metastasis(68.52%,74.51%)were higher than those in patients with tumor diameter≤2 cm(33.33%,33.33%),TNM stage Ta-T1(29.63%,31.37%),and non lymph node metastasis(31.48%,25.49%)(χ^(2)=5.777,4.932,11.848,P<0.05).Tumor diameter[hazard ratio(HR)=3.750],TNM stage(HR=1.972),lymph node metastasis(HR=1.166),and UBE2T(HR=4.679)were prognostic risk factors for patients with bladder cancer(P<0.05),and DKK3(HR=0.857)was a prognostic protective factor for patients with bladder cancer(P<0.05).There were 54 patients with negative expression of DKK3 who survived 31,19 patients with positive expression of DKK3 who survived 17,and survival was higher in patients with DKK3-positive expression than in DKK3-negative pati

关 键 词：膀胱癌 病理特征 预后 

分 类 号：R737.14[医药卫生—肿瘤]