物理修饰外泌体的研究进展  

Developments in the field of exosomes with physical modifications

作　　者：崔洪伟 马剑雄[1,2,3] 王岩 周丽芸[1,2,3,4] 李光 孙亚迪 李奕扬[1,2,3] 申佳慧 马天成 王祺钰 封潇添 董本超 杨培川 李岩 马信龙 Cui Hongwe;Ma Jianxiong;Wang Yan;Zhou Liyun;LiGuang;Sun Yadi;Li Yiyang;Shen Jiahuil;Ma Tianchen;Wang Qiyu;FengXiaotian;Dong Benchao;yang Peichuan;Li Yan;Ma Xinlong(Tianjin University Hospital,Tianjin 300211,China;Tianjin Orthopaedic Research Institute,Tianjin 300050,China;Tianjin Key Laboratory of Orthopaedic Biomechanics and Medical Engineering,Tianjin 300050,China;Medical Tech nology College of Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津大学天津医院(天津市天津医院)骨科研究所,天津300211 [2]天津市骨科研究所,天津300050 [3]天津市骨科生物力学与医学工程重点实验室,天津300050 [4]天津医科大学骨科临床学院,天津300050

出　　处：《中华实验外科杂志》2024年第7期1608-1615,共8页Chinese Journal of Experimental Surgery

基　　金：国家重点研发计划项目(2022YFC3601900);天津市自然科学基金重点项目(22JCZDJC00340);天津市卫生健康科技项目(TJWJ2022QN053)。

摘　　要：近年来,外泌体在生物医药领域的研究关注度显著升高,随着研究的不断深入,将其应用于临床的诊断和治疗是研究人员关注的热点。外泌体是细胞分泌的细胞外囊泡,携带核酸、蛋白质、等生物活性物质,在机体的生理和病理过程中发挥重要作用。与脂质体、纳米颗粒等合成载体比较,外泌体的内生性和异质性使其在疾病诊疗领域具有广泛而独特的优势。然而,外泌体的储存稳定性差、低产量、低纯度、和弱靶向性限制了其临床应用。可以通过物理修饰的方法探索并优化上述问题,本文通过检索大量文献,重点综述了各类物理修饰外泌体的最新研究进展,并对未来外泌体修饰的应用前景进行展望。Exosomes have received significant study interest in the field of biomedicine in recent years,and as the research progresses,their application to clinical diagnosis and therapy has become a hot topic among researchers.Exosomes are extracellular vesicles released by cells that contain nucleic acids,proteins,and other biologically active substances.They play a crucial part in the organism's physiological and pathological processes.Exosomes have a vast and distinct advantage over synthetic carriers such as liposomes and nanoparticles because they are endogenous and di-verse.Exosomes'clinical applicability is limited by their poor storage stability,low yield,low purity,and weak targe-ting.The above problems can be explored and optimized by physical modification.In this paper,by searching a large number of literatures,the latest research progress of various physically-modified exosomes is reviewed,and the future application prospect of exosome modification is prospected.

关 键 词：外泌体 物理修饰 细胞外囊泡 药物递送 靶向性 

分 类 号：R363[医药卫生—病理学]