基于连接组学技术的额叶胶质瘤患者脑网络结构与认知功能的关系  

Association between brain network structures based on the connectomics technology and cognitive function in patients with frontal glioma

作　　者：唐尧 范啸 程星 李金潭 张军霞[1] 尤永平[1] TANG Yao;FAN Xiao;CHENG Xing;LI Jintan;ZHANG Junxia;YOU Yongping(Department of Neurosurgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)

机构地区：[1]南京医科大学第一附属医院神经外科,江苏南京210029

出　　处：《国际神经病学神经外科学杂志》2024年第3期40-44,共5页Journal of International Neurology and Neurosurgery

基　　金：江苏省科教能力提升工程(ZDXK202225)。

摘　　要：目的利用连接组学技术探讨额叶胶质瘤对脑网络的累及模式,分析额叶胶质瘤患者脑网络和认知功能的关系。方法回顾性分析南京医科大学第一附属医院(江苏省人民医院)接受诊疗的45例额叶胶质瘤患者,运用连接组学技术创建患者个性化大脑网络图谱,分析额叶胶质瘤对传统功能结构和非传统功能网络的累及模式。前瞻性收集10例患者影像学和神经心理学资料,分析额叶胶质瘤脑网络与认知功能间的关系。结果回顾性研究中,45例患者中33例(73.33%)肿瘤累及传统的大脑功能结构(皮质脊髓束和语言区等);43例(95.56%)肿瘤累及非传统的大脑功能网络,最常累及中央执行网络(51.11%)和突显网络(44.44%)。前瞻性研究中,10例患者中有7例累及中央执行网络(70%),6例累及突显网络(60%);10例患者术前简易精神状态检查平均(19.63±8.51)分,蒙特利尔认知评估平均(14.34±7.62)分,均出现不同程度的认知功能减退。结论额叶胶质瘤不仅会累及大脑传统功能结构,还会累及非传统的功能脑网络。非传统功能网络的损伤常常导致患者出现认知功能障碍。Objective To investigate the involvement patterns of brain networks in frontal glioma using the connectomics technology,as well as the association between brain networks and cognitive function in patients with frontal glioma.Methods A retrospective analysis was performed for 45 patients with frontal glioma who were diagnosed and treated in The First Affiliated Hospital of Nanjing Medical University(Jiangsu Provincial People’s Hospital),and the connectomics technology was used to create an individualized brain network atlas and analyze the involvement patterns of frontal glioma on traditional functional structures and nontraditional functional networks.In a prospective study,imaging and neuropsychological data were collected from 10 patients to analyze the association between functional brain networks and cognitive function in frontal glioma.Results In the retrospective study,among the 45 patients,33(73.33%)had the involvement of traditional functional brain structures(including corticospinal tract and language regions)and 43(95.56%)had the involvement of nontraditional functional brain networks,mainly the central executive network(51.11%)and the salience network(44.44%).In the prospective study,among the 10 patients,7(70%)had the involvement of the central executive network and 6(60%)had the involvement of the salience network;the 10 patients had a mean preoperative Mini Mental State Examination score of 19.63±8.51 and a mean Montreal Cognitive Assessment score of 14.34±7.62,suggesting that they had varying degrees of cognitive decline.Conclusions Frontal glioma involves not only traditional functional structures but also nontraditional functional brain networks,and impairment of nontraditional functional networks often leads to cognitive dysfunction in patients.

关 键 词：额叶胶质瘤 认知功能 连接组学 大脑功能网络 

分 类 号：R739.41[医药卫生—肿瘤]