强制诱导言语治疗联合高频重复经颅磁刺激对脑卒中后运动性失语的疗效观察  

作　　者：马凯敏 俞坤强 周敏亚 吴李秀 

机构地区：[1]温州医科大学丽水二院,323000

出　　处：《浙江临床医学》2024年第7期1019-1021,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省基础公益研究计划(LGF19H17006,LGF20H170013)。

摘　　要：目的 观察强制诱导言语治疗联合高频重复经颅磁刺激(rTMS)对脑卒中后运动性失语的疗效。方法 选取2020年5月至2022年12月脑卒中运动性失语患者80例,随机分为对照组和观察组,每组各40例。对照组予强制诱导言语训练结合经颅磁伪刺激治疗,观察组予强制诱导言语训练联合高频rTMS治疗。比较两组治疗前后中国康复研究中心汉语标准失语症检查量表(CRRCAE)评分、日常生活交流能力量表(CADL)评分以及血清脑源性神经营养因子(BDNF)和胶质源性神经营养因子(GDNF)的变化。结果 观察组治疗后CRRCAE、CADL评分高于对照组,BDNF、GDNF水平高于对照组,差异均有统计学意义(P<0.05)。结论 强制诱导言语治疗联合高频rTMS可以改善脑卒中运动性失语患者的言语功能,其机制可能与促进BDNF和GDNF表达相关。Objective To explore the therapeutic effect of constraint induced aphasia therapy combined with high-frequency repetitive transcranial magnetic stimulation on post-stroke motor aphasia.Methods 80 stroke patients with motor aphasia from May 2019 to May 2021 were randomly divided into the control group and the observation group(40 cases in each group).The observation group received constraint induced aphasia therapy combined with high-frequency repetitive transcranial magnetic stimulation,while the control group received constraint induced aphasia therapy combined with transcranial magnetic pseudo-stimulation.The score of China rehabilitation research center aphasia examination(CRRCAE)and communication ability in daily living(CDAL)were recorded in the two groups before and after the treatment.The changes of serum brain-derived neurotrophic factor(BDNF)and glialderived neurotrophic factor(GDNF)levels were contrasted in the two groups before and after the treatment.Results Before the treatment,there was no significant difference in the scores of CRRCAE and CDAL between the two groups(P>0.05),the scores of CRRCAE and CDAL were higher than the control group after treatment,and the difference was significant(P<0.05).Before the treatment,there was no significant difference in the scores of BDNF and GDNF between two groups(P>0.05),the scores of BDNF and GDNF were higher in observation group,and the difference was significant(P<0.05).Conclusion Constraint induced aphasia therapy combined with high-frequency repetitive transcranial magnetic stimulation can better improve the speech function of stroke patients with motor aphasia,and its mechanism may be related to the promotion of BDNF and GDNF expression.

关 键 词：高频重复经颅磁刺激 强制诱导言语治疗 脑卒中 运动性失语 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]