皮肤颗粒细胞瘤10例临床及组织病理学特征分析  

Clinical and Histopathological Analysis for 10 Cases of Cutaneous Granular Cell Tumor

作　　者：白璐[1] 翟志芳 BAI Lu;ZHAI Zhifang(Department of Dermatology,the Hospital of No.80 Group Army of PLA,Weifang 261031,China;Department of Dermatology,the First Affiliated Hospital of Army Military Medical University,Chongqing 400038,China)

机构地区：[1]中国人民解放军陆军第八十集团军医院皮肤病科,山东潍坊261031 [2]陆军军医大学第一附属医院皮肤科,重庆400038

出　　处：《中国皮肤性病学杂志》2024年第8期881-886,共6页The Chinese Journal of Dermatovenereology

摘　　要：目的分析皮肤颗粒细胞瘤(granular cell tumor,GCT)患者的临床、组织病理学特征,对文献进行回顾复习,提高皮肤科医生对颗粒细胞瘤的认识,为临床诊治提供参考。方法回顾性分析2012年5月—2022年5月期间确诊的10例皮肤颗粒细胞瘤患者的临床表现、病理特征、免疫组织化学特点及治疗转归情况。结果10例皮肤颗粒细胞瘤患者皮损均为单发质硬的结节,多无自觉症状,直径均<2 cm,可发生于全身各部位,以头颈部及躯干多见。组织病理示:肿瘤位于真皮内,由大量梭形或上皮样细胞构成,胞浆内大量红色颗粒状物。10例患者肿瘤细胞S100、CD68均呈强阳性(10/10),9例神经元特异性烯醇化酶(NSE)阳性,1例瘤细胞部分阳性,8例增殖指数Ki67阳性细胞均低于2%,平滑肌肌动蛋白(SMA)均为阴性。10例患者手术切除后随访至少1年以上均无复发。结论颗粒细胞瘤是一种少见的软组织肿瘤,多为良性,临床多表现为单发质硬的结节,多无自觉症状,其诊断主要依据典型的组织病理学特点,临床治疗以手术切除为主,复发率低。Objective To analyze the clinical and histopathological characteristics of patients with cutaneous granular cell tumor(GCT),and review relevant literature to improve dermatologists′understanding of GCT and provide reference for clinical diagnosis and treatment.Methods A retrospective study was conducted on the clinical manifestations,histopathological and immunohistochemical characteristics,and treatment outcomes of 10 patients with GCT diagnosed from May 2012 to May 2022.Results The results showed that the skin lesions of 10 GCT patients were all single hard nodules,mostly asymptomatic,with a diameter of less than 2 cm,and located on various parts of the body,mainly on the head,neck,and trunk.Histopathologically,the tumors was within the dermis,which were composed of a large number of spindle shaped or epithelioid cells,with a large amount of red granules in the cytoplasm.Tumor cells showed strong positivity for S100 and CD68 in all of the 10 cases,positive for neuronal specific enolase(NSE)in nine cases and partially positive for NSE in one case.Smooth muscle actin(SMA)was negative in all the cases.In eight cases,the percentage of the cells with Ki67 positive was less than 2%.After surgical resection,no cases were observed recurrence in more than one-year follow-up.Conclusion GCT is a rare soft tissue tumor,mostly benign,clinically manifested as a soliary and firm nodule that is often asymptomatic.Its diagnosis is mainly based on the histopathological characteristics,and surgical resection is the preferred clinical treatment with a low recurrence rate.

关 键 词：颗粒细胞瘤 临床特征 组织病理 皮肤 

分 类 号：R739.5[医药卫生—肿瘤]