Exploring the Mechanism of Action of Gastrodin in Parkinson's Disease Based on Network Pharmacology  

作　　者：Feifan LIU Shifang LUO Yan WAN Linao ZHANG Xue WU Yuhuan XIE Peixin GUO 

机构地区：[1]College of Ethnic Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China [2]College of Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China [3]College of Basic Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China

出　　处：《Medicinal Plant》2024年第4期16-19,25,共5页药用植物：英文版

基　　金：National Natural Science Foundation of China(81660671);Science and Technology Plan Project of Science and Technology Department of Yunnan Province(202101AZ070001-172);Key Laboratory of Formulation Granules of Yunnan Province(202105AG070014);National Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project‘Dai Pharmacy’(zyyzdxk-2023192).

摘　　要：[Objectives]To explore the mechanism of action of gastrodin in the treatment of Parkinson's disease(PD)by employing network pharmacology technology,and to provide a scientific theoretical basis for the rational clinical application of gastrodin.[Methods]The target of gastrodin was identified through a search of the SwissTargetPrediction database.The keyword"Parkinson Disease"was employed to identify the pertinent targets of PD in the GeneCards and OMIM databases.The relationship between gastrodin and PD was elucidated,and a Veen map was constructed to identify the genes that were common to both.A total of 52 common drug targets associated with PD as identified in the Wayne chart were imported into the String database(https://string-db.org/)for protein-protein interaction prediction.Subsequently,Cytoscape 3.9.1 software was employed to construct a"drug-target"network.The potential targets of gastrodin in the treatment of PD were then imported into the DAVID database,where GO analysis and KEGG enrichment results were obtained.[Results]A total of 22 core targets and 53 related pathways of gastrodin were identified as potentially beneficial for the treatment of PD.[Conclusions]Gastrodin may be a potential therapeutic agent for the treatment of PD by modulating the biological process of apoptosis,affecting the relevant pathways such as the IL-17 signaling pathway and the TNF signaling pathway,and acting on GAPDH,EGFR,CASP3,MMP9 and other targets.

关 键 词：Parkinson's disease Network pharmacology GASTRODIN 

分 类 号：R285[医药卫生—中药学] R742.5[医药卫生—中医学]