Lyophilization Process of Hydroxypropyl Tetrahydropyrantriol Liposomes  

作　　者：Shengqian TIAN Enlong WANG Xin ZHANG Lili HE 

机构地区：[1]College of Pharmacy,Southwest Minzu University,Chengdu 610041,China

出　　处：《Medicinal Plant》2024年第4期35-39,共5页药用植物：英文版

基　　金：Youth Science Foundation Project of Sichuan Provincial Department of Science and Technology(2022NSFSC1437);Special Project of Scientific and Technological Research of Sichuan Provincial Administration of Traditional Chinese Medicine(2021MS121);Fundamental Research Funds for the Central Universities of Southwest Minzu University(ZYN2022040).

摘　　要：[Objectives]To enhance the skin permeability of hydroxypropyl tetrahydropyrantriol and provide a reference for the subsequent prevention or treatment of skin aging.[Methods]The lyophilization process of hydroxypropyl tetrahydropyrantriol liposomes was investigated using a single factor method,and a quality evaluation system was established based on the appearance,particle size,PDI,and re-dispersibility of the lyophilized samples.[Results]The lyophilization process of hydroxypropyl tetrahydropyrantriol liposomes was determined by single factor experiments.The pre-freezing period was 16 h at-80℃,the total drying time was 36 h,and the addition of 10%mannitol-sucrose was used as the lyoprotectant.[Conclusions]The product prepared by the lyophilization method exhibits a fluffy and full appearance,with minimal shrinkage and collapse.The volume remains consistent before and after lyophilization,and the re-dispersibility is satisfactory.The re-dissolution process is rapid,and the particle size and polydispersity index(PDI)remain largely unchanged before and after lyophilization.

关 键 词：Hydroxypropyl tetrahydropyrantriol LIPOSOME Lyoprotectant Lyophilization process 

分 类 号：R96[医药卫生—药理学] R75[医药卫生—药学] R318